Synthesis, structural characterization, antiradical and antidiabetic activities of copper(II) and zinc(II) Schiff base complexes derived from salicylaldehyde and beta-alanine
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18037491
DOI
10.1016/j.jinorgbio.2007.10.003
PII: S0162-0134(07)00280-2
Knihovny.cz E-resources
- MeSH
- Aldehydes chemistry MeSH
- beta-Alanine chemistry MeSH
- Diabetes Mellitus, Experimental prevention & control MeSH
- Spectrometry, Mass, Electrospray Ionization MeSH
- Hypoglycemic Agents chemical synthesis chemistry pharmacology MeSH
- Crystallography, X-Ray MeSH
- Copper chemistry MeSH
- Models, Molecular MeSH
- Molecular Structure MeSH
- Mice MeSH
- Free Radical Scavengers chemical synthesis chemistry pharmacology MeSH
- Spectrophotometry, Ultraviolet MeSH
- Spectroscopy, Fourier Transform Infrared MeSH
- Zinc chemistry MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Aldehydes MeSH
- beta-Alanine MeSH
- Hypoglycemic Agents MeSH
- Copper MeSH
- salicylaldehyde MeSH Browser
- Free Radical Scavengers MeSH
- Zinc MeSH
A series of copper(II) and zinc(II) complexes involving a tridentate O,N,O'-donor Schiff base derived from salicylaldehyde and beta-alanine {i.e. N-salicylidene-beta-alanine(2-), (L)}, having the composition [Cu(2)(L)(2)(H(2)O)].H(2)O (1), [Cu(L)(H(2)O)](n) (2), and [Zn(L)(H(2)O)](n) (3), have been prepared and characterized by elemental analyses, UV-visible (UV-VIS), FT-IR and ESI-MS spectra, and thermal analyses. Complexes 1 and 2 have been investigated by single crystal X-ray analysis and also by temperature dependent magnetic susceptibility measurements (294-80K). All prepared complexes have been evaluated by the antiperoxynitrite activity assay and alloxan-induced diabetes model. The significant antioxidant and antidiabetic activities have been found in the case of both copper(II) complexes 1 and 2. In spite of first two complexes, the zinc(II) complex 3, as well as the potassium salt of the ligand (KHL) showed only insignificant protective effect against the tyrosine nitration in vitro.
References provided by Crossref.org
Structural, magnetic and luminescent properties of lanthanide complexes with N-salicylideneglycine
