Lipoprotein(a) and its position among other risk factors of atherosclerosis
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18198982
DOI
10.33549/physiolres.931133
PII: 1133
Knihovny.cz E-resources
- MeSH
- Apoprotein(a) blood genetics MeSH
- Biomarkers blood MeSH
- Diabetes Mellitus, Type 2 complications MeSH
- Adult MeSH
- Risk Assessment MeSH
- Hypertension complications MeSH
- Coronary Disease etiology genetics metabolism MeSH
- Smoking adverse effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Lipids blood MeSH
- Lipoprotein(a) blood genetics MeSH
- Overweight complications MeSH
- Coronary Artery Disease etiology genetics metabolism MeSH
- Polymorphism, Genetic MeSH
- Promoter Regions, Genetic MeSH
- Risk Factors MeSH
- Aged MeSH
- Up-Regulation MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Apoprotein(a) MeSH
- Biomarkers MeSH
- Lipids MeSH
- Lipoprotein(a) MeSH
Lipoprotein(a) [Lp(a)] comprises of an LDL particle and apolipoprotein(a) [apo(a)] and its elevated levels are considered a risk factor for atherosclerosis. The aim of our study was to find out whether elevated Lp(a) levels are associated with increased risk of atherosclerosis in patients with multiple other risk factors. We further tested the association of three polymorphisms of the apo(a) gene promoter with Lp(a) levels. No significant correlation was detected between Lp(a) levels and lipid and clinical parameters tested. The study demonstrated a significantly (p=0.0219) elevated Lp(a) level (mean 28+/-35 mg/dl, median 0.14) in patients with coronary heart disease (CHD). In a group with premature CHD the correlation was not significant anymore. There was a significant correlation between polymorphic loci of the promoter region of apo(a) gene and Lp(a) levels (+93C T, p=0.0166, STR, p<0.0001). Our study suggests that elevated Lp(a) level is an independent risk factor of CHD in carriers of other important CHD risk factors. Observed association of sequence variants of the promoter of apo(a) gene with Lp(a) levels is caused in part due to linkage to a restricted range of apo(a) gene length isoforms.
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