The status and role of ErbB receptors in human cancer
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
18279851
DOI
10.1016/j.yexmp.2007.12.002
PII: S0014-4800(07)00146-3
Knihovny.cz E-resources
- MeSH
- ErbB Receptors physiology MeSH
- Humans MeSH
- Mice MeSH
- Biomarkers, Tumor physiology MeSH
- Neoplasms metabolism MeSH
- Signal Transduction physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- EGFR protein, human MeSH Browser
- ErbB Receptors MeSH
- Biomarkers, Tumor MeSH
Changes in the expression of cellular receptors contribute to the progression of many types of solid tumors. In this review, we focus on the normal role of ErbB receptors as signal transducers and their contribution to carcinogenesis when there are abnormalities in ErbB signaling due to the overactivity of the receptors or the overexpression of ligands, which can lead to developmental defects and have been associated with many types of cancers.
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