Cytokine production was determined in vitro after stimulation with three different Neisseria meningitidis (NM) strains. Virulent NM B strain isolated from a patient with mild course of invasive meningococcal disease (IMD) elicited higher cytokine production than NM B and NM C hypervirulent strains isolated from patients with moderate and fatal course of IMD, respectively. Endotoxin concentration after in vitro stimulation correlated with cytokine production: the highest endotoxin levels were observed with virulent NM B strain. Serum cytokines and endotoxin levels showed an opposite trend. These results suggest that inflammatory response during IMD is predominantly influenced by host factors.

3rd Department of Infectious and Tropical Diseases 1st Faculty of Medicine Charles University Prague Prague Czechia

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Crit Rev Microbiol. 1998;24(4):281-334 PubMed

Clin Microbiol Rev. 2000 Jan;13(1):144-66, table of contents PubMed

Crit Care. 2002 Feb;6(1):60-5 PubMed

Cent Eur J Public Health. 2003 Dec;11 Suppl:S62-7 PubMed

Infect Immun. 2006 Feb;74(2):1360-7 PubMed

Mol Microbiol. 1992 Mar;6(5):591-7 PubMed

J Clin Pathol. 2003 Jun;56(6):417-22 PubMed

J Clin Immunol. 2000 Jan;20(1):46-53 PubMed

Clin Exp Immunol. 1998 Nov;114(2):215-9 PubMed

Lancet. 1992 Dec 5;340(8832):1379-81 PubMed

N Engl J Med. 2001 May 3;344(18):1378-88 PubMed

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