Modification of respiratory-chain enzyme activities in brown adipose tissue mitochondria by idebenone (hydroxydecyl-ubiquinone)
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Enzyme Activation drug effects MeSH
- Adipose Tissue, Brown drug effects enzymology MeSH
- Cricetinae MeSH
- Cells, Cultured MeSH
- Mitochondria drug effects metabolism MeSH
- Electron Transport physiology MeSH
- Ubiquinone administration & dosage analogs & derivatives MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Cricetinae MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- idebenone MeSH Browser
- Ubiquinone MeSH
Idebenone (IDE), a synthetic analog of coenzyme Q, strongly activates glycerol phosphate (GP) oxidation in brown adipose tissue mitochondria. GP oxidase, GP cytochrome c oxidoreductase and GP dehydrogenase activities were all significantly stimulated by 13 muM IDE. Substituted derivatives of IDE acetyl- and methoxyidebenone had similar activating effects. When succinate was used as substrate, no activation by IDE could be observed. The activation effect of IDE could be explained as release of the inhibition of glycerol phosphate dehydrogenase by endogenous free fatty acids. NADH oxidoreductase activity and oxidation of NADH-dependent substrates were inhibited by IDE. The extent of the inhibition and IDE concentration dependence varied when various substrates were tested, being highest for pyruvate and lowest for 2-oxoglutarate. This study thus showed that the effect of IDE on various mitochondrial enzymes is very different and thus its therapeutic use should take into account its specific effect on various mitochondrial dehydrogenases in relation to particular defects of mitochondrial respiratory chain.
See more in PubMed
Arch Biochem Biophys. 1996 Jun 15;330(2):395-400 PubMed
Mol Genet Metab. 2002 Sep-Oct;77(1-2):21-30 PubMed
Arch Biochem Biophys. 1997 Aug 1;344(1):235-41 PubMed
Biochem Biophys Res Commun. 2006 Jan 6;339(1):362-6 PubMed
Mitochondrion. 2007 Jun;7 Suppl:S8-33 PubMed
J Biol Chem. 2004 Jun 25;279(26):27278-85 PubMed
Mol Cell Biochem. 1975 Apr 30;7(1):45-50 PubMed
J Biol Chem. 2005 Jun 3;280(22):21295-312 PubMed
Mitochondrion. 2007 Jun;7 Suppl:S103-11 PubMed
Neurology. 2004 Feb 10;62(3):524-5; author reply 525; discussion 525 PubMed
Biochim Biophys Acta. 2007 Jul;1767(7):989-97 PubMed
J Bioenerg Biomembr. 1989 Dec;21(6):649-62 PubMed
Arch Gerontol Geriatr. 1990 Nov-Dec;11(3):177-86 PubMed
J Bioenerg Biomembr. 1995 Dec;27(6):583-96 PubMed
Methods Enzymol. 1979;55:65-78 PubMed
J Biol Chem. 1951 Nov;193(1):265-75 PubMed
Eur J Biochem. 1973 Apr;34(2):358-68 PubMed
Biochemistry. 1996 Feb 27;35(8):2705-16 PubMed
Neurochem Res. 2007 Apr-May;32(4-5):723-7 PubMed
J Bioenerg Biomembr. 1992 Apr;24(2):235-41 PubMed
Int J Biochem. 1984;16(2):243-5 PubMed
Biochim Biophys Acta. 2004 Jan 28;1660(1-2):171-99 PubMed
Biochim Biophys Acta. 1998 May 6;1364(2):222-35 PubMed
Biochem Biophys Res Commun. 2004 Apr 16;316(4):1138-42 PubMed
J Bioenerg Biomembr. 2002 Apr;34(2):105-13 PubMed
Curr Neurovasc Res. 2005 Dec;2(5):447-59 PubMed
Acta Biochim Pol. 2003;50(2):405-13 PubMed
Gen Physiol Biophys. 2003 Mar;22(1):93-102 PubMed
J Physiol. 2003 Oct 15;552(Pt 2):335-44 PubMed
Ann N Y Acad Sci. 2006 May;1067:47-55 PubMed
FEBS Lett. 1993 Oct 11;332(1-2):127-31 PubMed
Exp Biol Med (Maywood). 2003 May;228(5):506-13 PubMed
CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease
Coenzyme Q10 effects in neurological diseases
