Porphyrin-bile acid conjugates: from saccharide recognition in the solution to the selective cancer cell fluorescence detection
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18421385
DOI
10.1039/b717528k
Knihovny.cz E-resources
- MeSH
- Apoptosis drug effects MeSH
- Cell Line MeSH
- 3T3 Cells MeSH
- Microscopy, Fluorescence methods MeSH
- Photochemotherapy methods MeSH
- DNA Fragmentation drug effects MeSH
- Glycosylation MeSH
- HeLa Cells MeSH
- Humans MeSH
- Ligands MeSH
- Molecular Structure MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Biomarkers, Tumor analysis MeSH
- Neoplasms diagnosis drug therapy MeSH
- Porphyrins chemistry pharmacology MeSH
- Cell Proliferation drug effects MeSH
- Solutions chemistry MeSH
- Carbohydrates chemistry MeSH
- Drug Screening Assays, Antitumor MeSH
- Sensitivity and Specificity MeSH
- Cell Line, Transformed MeSH
- Binding Sites MeSH
- Dose-Response Relationship, Drug MeSH
- Structure-Activity Relationship MeSH
- Bile Acids and Salts chemistry pharmacology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Ligands MeSH
- Biomarkers, Tumor MeSH
- Porphyrins MeSH
- Solutions MeSH
- Carbohydrates MeSH
- Bile Acids and Salts MeSH
This paper describes the preparation and use of conjugates of porphyrins and bile acids as ligands to bind to tumor expressed saccharides. Bile acid-porphyrin conjugates were tested for recognition of saccharides that are typically present on malignant tumor cells. Fluorescence microscopy, in vitro PDT cell killing, and PDT of subcutaneous 4T1 mouse tumors is reported. High selectivity for saccharide cancer markers and cancer cells was observed. This in vivo and in vitro study demonstrated high potential use for these compounds in targeted photodynamic therapy.
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