On the structure of motor symptoms of Parkinson's disease
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18464275
DOI
10.1002/mds.22029
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Dyskinesias etiology physiopathology MeSH
- Hypokinesia etiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Neurologic Examination MeSH
- Parkinson Disease complications physiopathology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Muscle Rigidity etiology MeSH
- Tremor etiology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
This study aims to investigate the structure of the motor symptoms of Parkinson's disease (PD), as measured by the Motor Section of the Unified Parkinson's Disease Rating Scale (UPDRS). The dimensionality of the Motor Section of the UPDRS was studied using structural equation modeling. The UPDRS measures were obtained from 405 patients with PD [237 men (39 "off", 170 "on", 28 unknown) and 168 women (21 "off", 140 "on", 7 unknown)]. The ordinal character of UPDRS scores and sample size substantiated the use of robust diagonally weighted least squares model estimation. It was shown that the Motor Section of the UPDRS incorporates five main latent symptom factors (rigidity, tremor, bradykinesia of the extremities, axial/gait bradykinesia, speech/hypomimia) plus two additional factors for laterality, which account for asymmetry of tremor, rigidity and bradykinesia of the extremities. Tremor seems to be an independent symptom factor of PD. Other latent variables are substantially correlated.
References provided by Crossref.org
Changes of hand preference in Parkinson's disease
