Gadolinium(III) complexes as MRI contrast agents: ligand design and properties of the complexes
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
18521444
DOI
10.1039/b719704g
Knihovny.cz E-resources
- MeSH
- Gadolinium chemistry MeSH
- Cations MeSH
- Kinetics MeSH
- Contrast Media chemical synthesis MeSH
- Lanthanoid Series Elements chemistry MeSH
- Ligands MeSH
- Magnetic Resonance Imaging methods MeSH
- Models, Molecular MeSH
- Organometallic Compounds chemical synthesis MeSH
- Thermodynamics MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Gadolinium MeSH
- Cations MeSH
- Contrast Media MeSH
- Lanthanoid Series Elements MeSH
- Ligands MeSH
- Organometallic Compounds MeSH
Magnetic resonance imaging is a commonly used diagnostic method in medicinal practice as well as in biological and preclinical research. Contrast agents (CAs), which are often applied are mostly based on Gd(III) complexes. In this paper, the ligand types and structures of their complexes on one side and a set of the physico-chemical parameters governing properties of the CAs on the other side are discussed. The solid-state structures of lanthanide(III) complexes of open-chain and macrocyclic ligands and their structural features are compared. Examples of tuning of ligand structures to alter the relaxometric properties of gadolinium(III) complexes as a number of coordinated water molecules, their residence time (exchange rate) or reorientation time of the complexes are given. Influence of the structural changes of the ligands on thermodynamic stability and kinetic inertness/lability of their lanthanide(III) complexes is discussed.
References provided by Crossref.org
Luminescent Sensor Based on Ln(III) Ternary Complexes for NAD(P)H Detection
