Re-expression of nestin in the myocardium of postinfarcted patients
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Cytoskeleton metabolism MeSH
- Adult MeSH
- Myocardial Infarction metabolism pathology MeSH
- Intermediate Filaments metabolism MeSH
- Myocytes, Cardiac metabolism pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Myocardium metabolism pathology MeSH
- Nestin MeSH
- Intermediate Filament Proteins genetics metabolism MeSH
- Nerve Tissue Proteins genetics metabolism MeSH
- Gene Expression Regulation MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- NES protein, human MeSH Browser
- Nestin MeSH
- Intermediate Filament Proteins MeSH
- Nerve Tissue Proteins MeSH
Intact cardiac muscle cells in the adult heart do not express intermediate filament nestin. In this study, we report on widespread expression of intermediate filament nestin in human myocardium of patients who died from the myocardial infarction. Nestin was detected in cardiomyocytes, endothelial cells, and few interstitial cells. Elevated levels of nestin were observed in cardiac muscle cells in all specimens, although the intensity of immunoreactivity and distribution of the signal differed. The strongest immunoreactivity was observed from 4 days after myocardial infarction in the infarction border zone where nestin was distributed homogeneously in the entire sarcoplasm of cardiac muscle cells. Within the following week, nestin in immunoreactive cardiomyocytes was redistributed and restricted to small subsarcolemmal foci and to intercalated discs. Angiogenic capillaries that grew between vital nestin-positive cardiomyocytes and entered the necrotic area expressed also high levels of nestin. Nestin-positive endothelial cells were often observed in mutual interactions with nestin-positive cardiac muscle cells. These findings document a crucial role of nestin in remodeling cytoskeleton of cells in the human postinfarcted myocardium.
See more in PubMed
Circ Res. 2004 Oct 29;95(9):911-21 PubMed
Science. 1997 Apr 4;276(5309):71-4 PubMed
J Clin Invest. 2005 Feb;115(2):326-38 PubMed
Acta Medica (Hradec Kralove). 1998;41(2):73-80 PubMed
J Cell Biol. 2005 Sep 26;170(7):1135-46 PubMed
Cardiovasc Res. 1993 Aug;27(8):1387-403 PubMed
Stem Cells Dev. 2004 Dec;13(6):658-64 PubMed
N Engl J Med. 2001 Jun 7;344(23):1750-7 PubMed
Heart. 2000 Dec;84(6):659-67 PubMed
Ann N Y Acad Sci. 2001 Jun;938:231-3; discussion 233-5 PubMed
J Cell Physiol. 2005 Jul;204(1):51-62 PubMed
Science. 2001 Oct 19;294(5542):559-63 PubMed
Nature. 2001 Apr 5;410(6829):701-5 PubMed
Cell. 1990 Feb 23;60(4):585-95 PubMed
J Neurosci. 1988 Apr;8(4):1144-51 PubMed
Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8692-7 PubMed
Science. 2004 May 28;304(5675):1338-40 PubMed
Am J Pathol. 1999 Feb;154(2):591-600 PubMed
Circ Res. 1997 Feb;80(2):281-9 PubMed
J Cell Sci. 1993 Dec;106 ( Pt 4):1291-300 PubMed
Stem Cells. 2006 May;24(5):1236-45 PubMed
J Biol Chem. 1999 Apr 2;274(14):9881-90 PubMed
Science. 2002 Oct 18;298(5593):597-600 PubMed
Cell. 2003 Sep 19;114(6):763-76 PubMed
Folia Biol (Praha). 1998;44(5):155-61 PubMed
Circulation. 2002 Oct 8;106(15):1913-8 PubMed
Int J Cardiol. 2004 Oct;97(1):123-7 PubMed
J Histochem Cytochem. 1995 Aug;43(8):843-7 PubMed
FASEB J. 2008 Apr;22(4):1021-31 PubMed
Analysis of nuclear nestin localization in cell lines derived from neurogenic tumors
