Re-expression of nestin in the myocardium of postinfarcted patients
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- cytoskelet metabolismus MeSH
- dospělí MeSH
- infarkt myokardu metabolismus patologie MeSH
- intermediární filamenta metabolismus MeSH
- kardiomyocyty metabolismus patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- myokard metabolismus patologie MeSH
- nestin MeSH
- proteiny intermediálních filament genetika metabolismus MeSH
- proteiny nervové tkáně genetika metabolismus MeSH
- regulace genové exprese MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- NES protein, human MeSH Prohlížeč
- nestin MeSH
- proteiny intermediálních filament MeSH
- proteiny nervové tkáně MeSH
Intact cardiac muscle cells in the adult heart do not express intermediate filament nestin. In this study, we report on widespread expression of intermediate filament nestin in human myocardium of patients who died from the myocardial infarction. Nestin was detected in cardiomyocytes, endothelial cells, and few interstitial cells. Elevated levels of nestin were observed in cardiac muscle cells in all specimens, although the intensity of immunoreactivity and distribution of the signal differed. The strongest immunoreactivity was observed from 4 days after myocardial infarction in the infarction border zone where nestin was distributed homogeneously in the entire sarcoplasm of cardiac muscle cells. Within the following week, nestin in immunoreactive cardiomyocytes was redistributed and restricted to small subsarcolemmal foci and to intercalated discs. Angiogenic capillaries that grew between vital nestin-positive cardiomyocytes and entered the necrotic area expressed also high levels of nestin. Nestin-positive endothelial cells were often observed in mutual interactions with nestin-positive cardiac muscle cells. These findings document a crucial role of nestin in remodeling cytoskeleton of cells in the human postinfarcted myocardium.
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