Lateralization of hippocampal nitric oxide mediator system in people with Alzheimer disease, multi-infarct dementia and schizophrenia
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18647632
DOI
10.1016/j.neuint.2008.06.009
PII: S0197-0186(08)00104-6
Knihovny.cz E-resources
- MeSH
- Alzheimer Disease metabolism pathology MeSH
- Arginine metabolism MeSH
- Citrulline metabolism MeSH
- Nitrates metabolism MeSH
- Nitrites metabolism MeSH
- Functional Laterality MeSH
- Glutamine metabolism MeSH
- Hippocampus metabolism pathology MeSH
- Isoenzymes metabolism MeSH
- Humans MeSH
- Dementia, Multi-Infarct metabolism pathology MeSH
- Nitric Oxide metabolism MeSH
- Schizophrenia metabolism pathology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Signal Transduction MeSH
- Nitric Oxide Synthase metabolism MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Arginine MeSH
- Citrulline MeSH
- Nitrates MeSH
- Nitrites MeSH
- Glutamine MeSH
- Isoenzymes MeSH
- Nitric Oxide MeSH
- Nitric Oxide Synthase MeSH
There is evidence that brain lateralization underlying hemispheric specialization can be observed also at biochemical level. However, hemispheric differences in nitric oxide mediator system have not yet been evaluated. The hippocampus and planum temporale are highly asymmetrical regions but the degree of their laterality is altered in demented or psychotic people. In the study, l-glutamate/l-arginine/l-citrulline concentrations, nitric oxide synthase activities/expressions and nitrites/nitrates levels were estimated in autoptic hippocampi. Right/left laterality in endothelial synthase activity and in nitrites/nitrates was observed in controls. Lateral changes were estimated in patients with Alzheimer disease (a marked increase in activities of constitutive synthases and in expression of inducible enzyme in the left side) and schizophrenia (an increase in activities of all enzymes especially in the right side). Significant shifts from positive to negative correlations were found between laterality of some components of nitric oxide pathway and of planum temporale volumetry under pathological conditions. The hippocampal nitric oxide system appears to be globally right/left lateralized, especially via actions of highly asymmetrical endothelial synthase. The results suggest a specific involvement of all synthases in the development of selected diseases and show that lateral analyses are of sufficient sensitivity to reveal subtle links. The volumetric asymmetry of the planum temporale as a marker of handedness is not probably simply linked to brain laterality at biochemical level but reflects alterations due to pathological processes.
References provided by Crossref.org
Endogenous Modulators of NMDA Receptor Control Dendritic Field Expansion of Cortical Neurons
Aging and lateralization of the rat brain on a biochemical level
