Lateralization of 17beta-hydroxysteroid dehydrogenase type 10 in hippocampi of demented and psychotic people
Language English Country Switzerland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18765932
DOI
10.1159/000151778
PII: 000151778
Knihovny.cz E-resources
- MeSH
- 3-Hydroxyacyl CoA Dehydrogenases genetics metabolism MeSH
- Alzheimer Disease pathology physiopathology MeSH
- Amyloid beta-Peptides metabolism MeSH
- Cerebral Infarction pathology physiopathology MeSH
- Functional Laterality physiology MeSH
- Hippocampus enzymology pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- RNA, Messenger metabolism MeSH
- Mitochondria enzymology MeSH
- Psychotic Disorders pathology physiopathology MeSH
- Gene Expression Regulation, Enzymologic MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 3-Hydroxyacyl CoA Dehydrogenases MeSH
- Amyloid beta-Peptides MeSH
- HSD17B10 protein, human MeSH Browser
- RNA, Messenger MeSH
OBJECTIVE: The multifunctional mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type 10 could play a role in the development of Alzheimer disease via its high-affinity binding to amyloid-beta peptides and its overexpression. METHODS: We evaluated the specificity of alterations in mRNA/enzyme expression levels in human right and left hippocampi. RESULTS: We observed a trend towards right/left laterality in nondemented nonpsychotic controls; however, the degree of asymmetry was higher for mRNA when compared to enzyme expression levels. In Alzheimer disease and schizophrenia, significant shifts to left/right asymmetry were found and the changes were associated with more marked increases in mRNA/enzyme expression in the left hemisphere. On the other hand, no alterations were observed in people with multi-infarct dementia. CONCLUSION: Our results support studies reporting an impairment of mitochondria in Alzheimer disease or schizophrenia and a higher vulnerability of the dominant hemisphere to pathological processes. Overexpression of the enzyme could be used to distinguish Alzheimer disease from multi-infarct dementia.
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Aging and lateralization of the rat brain on a biochemical level
