Lateralization of 17beta-hydroxysteroid dehydrogenase type 10 in hippocampi of demented and psychotic people
Jazyk angličtina Země Švýcarsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
18765932
DOI
10.1159/000151778
PII: 000151778
Knihovny.cz E-zdroje
- MeSH
- 3-hydroxyacyl-CoA-dehydrogenasy genetika metabolismus MeSH
- Alzheimerova nemoc patologie patofyziologie MeSH
- amyloidní beta-protein metabolismus MeSH
- cerebrální infarkt patologie patofyziologie MeSH
- funkční lateralita fyziologie MeSH
- hipokampus enzymologie patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- messenger RNA metabolismus MeSH
- mitochondrie enzymologie MeSH
- psychotické poruchy patologie patofyziologie MeSH
- regulace genové exprese enzymů MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 3-hydroxyacyl-CoA-dehydrogenasy MeSH
- amyloidní beta-protein MeSH
- HSD17B10 protein, human MeSH Prohlížeč
- messenger RNA MeSH
OBJECTIVE: The multifunctional mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type 10 could play a role in the development of Alzheimer disease via its high-affinity binding to amyloid-beta peptides and its overexpression. METHODS: We evaluated the specificity of alterations in mRNA/enzyme expression levels in human right and left hippocampi. RESULTS: We observed a trend towards right/left laterality in nondemented nonpsychotic controls; however, the degree of asymmetry was higher for mRNA when compared to enzyme expression levels. In Alzheimer disease and schizophrenia, significant shifts to left/right asymmetry were found and the changes were associated with more marked increases in mRNA/enzyme expression in the left hemisphere. On the other hand, no alterations were observed in people with multi-infarct dementia. CONCLUSION: Our results support studies reporting an impairment of mitochondria in Alzheimer disease or schizophrenia and a higher vulnerability of the dominant hemisphere to pathological processes. Overexpression of the enzyme could be used to distinguish Alzheimer disease from multi-infarct dementia.
Citace poskytuje Crossref.org
Aging and lateralization of the rat brain on a biochemical level
