A distinctive translocation carcinoma of the kidney ["rosette-like forming," t(6;11), HMB45-positive renal tumor]
Language English Country Netherlands Media print-electronic
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Antigens, Neoplasm analysis MeSH
- Adult MeSH
- Carcinoma, Renal Cell chemistry genetics MeSH
- Humans MeSH
- Melanoma-Specific Antigens MeSH
- Young Adult MeSH
- Pregnancy Complications, Neoplastic genetics MeSH
- Neoplasm Proteins analysis MeSH
- Kidney Neoplasms chemistry genetics MeSH
- Pregnancy MeSH
- Translocation, Genetic * MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antigens, Neoplasm MeSH
- Melanoma-Specific Antigens MeSH
- Neoplasm Proteins MeSH
OBJECTIVE: Recently, a novel renal carcinoma with specific clinical and histological characteristics and translocation t(6;11)(p21.1;q12 or q13) has been identified. We have found 11 cases in the literature, and we are adding another 3 cases. MATERIALS AND METHODS: Three cases were found in the Plzen pathological register with approximately 15,000 cases of kidney tumors. There were two females and 1 male, aged 22, 24, and 39 years. RESULTS: The sizes of the tumors were 40, 136, and 10 mm. Two tumors were found incidentally; the biggest one was self-palpated by a 24-year-old pregnant patient. Patients are without any signs of disease 42, 20, and 17 months after surgery. CONCLUSION: This tumor is a distinctive and rare translocation carcinoma of the kidney [t(6;11), HMB45 positive]. All cases with known clinical data arose in younger people. The malignant potential is probably low.
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