Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?
Language English Country Switzerland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Biomarkers MeSH
- Crohn Disease blood MeSH
- Electrophoresis, Polyacrylamide Gel MeSH
- Escherichia coli metabolism MeSH
- Fluorescein-5-isothiocyanate MeSH
- Fluorescent Dyes MeSH
- Galectin 3 blood MeSH
- Inflammatory Bowel Diseases blood chemically induced diagnosis MeSH
- Immunohistochemistry MeSH
- Colitis chemically induced MeSH
- Colon metabolism MeSH
- Lectins metabolism MeSH
- Humans MeSH
- Lipopolysaccharide Receptors analysis metabolism MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Dextran Sulfate MeSH
- Colitis, Ulcerative blood MeSH
- Blotting, Western MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
- Fluorescein-5-isothiocyanate MeSH
- Fluorescent Dyes MeSH
- Galectin 3 MeSH
- Lectins MeSH
- Lipopolysaccharide Receptors MeSH
- Dextran Sulfate MeSH
OBJECTIVE: It is an open question whether multifunctional galectin-3 can be a serum marker in inflammatory bowel disease. METHODS: Western blots and commercial ELISA detected and quantitated the lectin immunocytochemistry using double labeling localized it in tissue sections. RESULTS: Serum concentrations were significantly increased in specimen of patients with active and remission-stage ulcerative colitis and Crohn's disease, associated with emerging positivity of CD14(+) cells. CONCLUSION: Enhanced concentration of galectin-3 in serum reflects presence of disease and points to its involvement in the pathogenesis.
See more in PubMed
Clin Exp Immunol. 2007 Oct;150(1):13-21 PubMed
Glycoconj J. 2004;19(7-9):575-81 PubMed
Thyroid. 2008 Jul;18(7):705-12 PubMed
J Histochem Cytochem. 1990 Nov;38(11):1625-31 PubMed
Biochemistry. 2005 Sep 20;44(37):12564-71 PubMed
Gastroenterology. 1990 Mar;98(3):694-702 PubMed
Inflamm Bowel Dis. 2007 Oct;13(10):1202-11 PubMed
J Clin Immunol. 2001 Sep;21(5):348-56 PubMed
Immunol Rev. 2005 Aug;206:260-76 PubMed
J Clin Microbiol. 2005 Jul;43(7):3380-9 PubMed
Biochim Biophys Acta. 2006 Apr;1760(4):616-35 PubMed
Bone. 2008 Nov;43(5):945-50 PubMed
Eur J Gastroenterol Hepatol. 1997 Sep;9(9):893-9 PubMed
Lab Invest. 1993 Aug;69(2):238-49 PubMed
Gastroenterol Clin North Am. 2005 Sep;34(3):401-12, vii-viii PubMed
Biochim Biophys Acta. 2008 Apr;1780(4):716-22 PubMed
Immunol Rev. 2005 Aug;206:149-59 PubMed
Cytometry A. 2008 Feb;73(2):139-47 PubMed
J Gastroenterol. 2006 Jan;41(1):10-6 PubMed
Eur J Gastroenterol Hepatol. 2002 Feb;14(2):145-52 PubMed
Histochemistry. 1991;95(3):269-77 PubMed
Ann N Y Acad Sci. 2005 Jun;1051:787-98 PubMed
Clin Cancer Res. 2000 Apr;6(4):1389-93 PubMed
Crit Rev Immunol. 2006;26(1):43-79 PubMed
Circulation. 2004 Nov 9;110(19):3121-8 PubMed
J Immunol. 2000 Aug 15;165(4):2156-64 PubMed
Folia Biol (Praha). 2007;53(4):109-28 PubMed
Eur J Cancer. 2004 Oct;40(15):2324-30 PubMed
J Pediatr Gastroenterol Nutr. 2002 May-Jun;34 Suppl 1:S33-9 PubMed
Histochem Cell Biol. 2008 Sep;130(3):567-81 PubMed
Immunol Lett. 2004 May 15;93(2-3):97-108 PubMed
Eur J Biochem. 1997 Feb 1;243(3):543-76 PubMed
J Cancer Res Clin Oncol. 1999 Aug-Sep;125(8-9):461-74 PubMed
Folia Biol (Praha). 1999;45(4):157-62 PubMed
Inflamm Bowel Dis. 2007 Jan;13(1):91-6 PubMed
Inflamm Bowel Dis. 2006 Jun;12(6):429-36 PubMed
FEBS J. 2007 Jul;274(13):3233-56 PubMed
J Biol Chem. 2001 Sep 21;276(38):35917-23 PubMed
J Biol Chem. 2004 Mar 19;279(12):10841-7 PubMed
J Immunol. 2001 Sep 1;167(5):2651-6 PubMed
Folia Microbiol (Praha). 2001;46(6):565-72 PubMed
Antimicrob Agents Chemother. 2008 Feb;52(2):427-34 PubMed
N Engl J Med. 2005 Dec 8;353(23):2462-76 PubMed
J Dig Dis. 2007 Nov;8(4):171-8 PubMed
Inflamm Bowel Dis. 2006 Apr;12(4):304-10 PubMed
Int Arch Allergy Immunol. 2003 Jul;131(3):209-11 PubMed
Gastroenterology. 2001 Feb;120(3):622-35 PubMed
N Engl J Med. 1987 Dec 24;317(26):1625-9 PubMed
Histol Histopathol. 1993 Apr;8(2):369-83 PubMed
Inflamm Bowel Dis. 2006 Jul;12(7):588-97 PubMed
