Serotonin-depleted rats are capable of learning in active place avoidance, a spatial task requiring cognitive coordination
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19397387
DOI
10.33549/physiolres.931729
PII: 1729
Knihovny.cz E-resources
- MeSH
- Serotonin Antagonists pharmacology MeSH
- Fenclonine pharmacology MeSH
- Cognition drug effects physiology MeSH
- Rats MeSH
- Motor Activity drug effects physiology MeSH
- Rats, Long-Evans MeSH
- Serotonin metabolism MeSH
- Avoidance Learning drug effects physiology MeSH
- Space Perception drug effects physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Serotonin Antagonists MeSH
- Fenclonine MeSH
- Serotonin MeSH
Neurotransmitter substrate of spatial cognition belongs to current topics in behavioral neuroscience. The present study examined the effects of serotonin depletion with p-chlorophenylalanine on learning of rats in active place avoidance, a spatial task requiring allothetic mapping and cognitive coordination and highly dependent upon hippocampus. Serotonin depletion transiently increased locomotor activity in response to footshocks, but it did not change the avoidance efficiency measured by three spatial parameters. These results suggest that serotonin neurotransmission is not crucial for cognitive coordination and allothetic learning, i.e. the processes, which are crucial for active place avoidance performance.
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