The levels of prealbumin (PAB, transthyretin) were determined and evaluated in the cerebrospinal fluid (CSF) and serum in various subgroups of the multiple sclerosis (MS) patients. In severely disabled patients, serum PAB was elevated more frequently. CSF and serum PAB concentrations were higher in treated than in nontreated patients; the values above the upper reference limits were also more frequently found in treated patients. PAB index showed a tendency to decrease during the course of the disease. The routine determination of PAB in CSF and serum is, therefore, recommended to be recognized in MS patients as a substantial clinical value and, thus, be comprised, including also immunoglobulins and other parameters, into the spectrum of characteristics in Protein Panel.

Laboratory of Reference for CSF and Neuroimmunology Department of Clinical Biochemistry Homolka Hospital Prague Czech Republic

Zobrazit více v PubMed

Sb Lek. 2003;104(1):1-12 PubMed

Eur J Neurol. 2006 Sep;13(9):913-22 PubMed

Folia Microbiol (Praha). 2003;48(6):839-47 PubMed

Acta Neurol Scand. 2001 Aug;104(2):72-7 PubMed

Clin Chim Acta. 2003 Aug;334(1-2):107-10 PubMed

J Neurol. 2003 Mar;250(3):371-2; author reply 372 PubMed

Acta Cytol. 2001 Jan-Feb;45(1):51-9 PubMed

Clin Chem Lab Med. 2003 Mar;41(3):331-7 PubMed

Acta Neurol Scand. 2005 Aug;112(2):97-102 PubMed

Folia Microbiol (Praha). 2007;52(5):529-34 PubMed

Neurology. 1983 Nov;33(11):1444-52 PubMed

Ann Neurol. 2001 Jul;50(1):121-7 PubMed

Acta Neurol Scand. 2000 Feb;101(2):89-94 PubMed

Neurology. 1975 Jun;25(6):537-46 PubMed

Adv Clin Chem. 2001;36:1-62 PubMed

Neurology. 1987 Jul;37(7):1262-3 PubMed

Folia Microbiol (Praha). 2006;51(5):485-91 PubMed

Clin Chim Acta. 1982 Sep 30;124(3):339-41 PubMed

Cryptococcal meningitis--a follow-up study of a serious clinical entity: quick cytological and microbiological diagnostics using a special staining procedure in cerebrospinal fluid specimens