In a group of 10,156 patients with neurological diseases, the IgM level was assessed (using laser nephelometry) both in cerebrospinal fluid (CSF) and serum; concentration of other 17 protein fractions was also simultaneously determined: albumin, immunoglobulins, acute phase reactants, complement components, apolipoproteins, proteinase inhibitors and alpha1-microglobulin. Total protein, element counts and glucose level were also evaluated. In patients with normal CSF findings, only limited statistically significant correlations were demonstrated between IgM and other CSF protein fractions while, in the group of patients with pathological CSF findings, significant correlations were found between CSF(IgM) and other immunoglobulins, complement fractions and the rate of intrathecal synthesis of immunoglobulins. Correlations were also found between CSF(IgM) and CSF antithrombin-III and alpha1-microglobulin. Correlations between CSF(IgM) and CSF apolipoproteins support the theory of CNS tissue destruction whenever the concentration of CSF apolipoproteins is elevated. Our data substantially contribute to establishing the diagnosis in patients with neurological diseases; simultaneous measurement of a high number of CSF proteins is becoming inevitable for a reasonable assessment of the CSF Protein Status.

Department of Clinical Biochemistry Laboratory of Reference for CSF and Neuroimmunology Homolka Hospital 150 30 Prague Czechia

See more in PubMed

Acta Neurol Scand. 1987 Mar;75(3):201-8 PubMed

Clin Chim Acta. 2003 Aug;334(1-2):107-10 PubMed

J Neurol Neurosurg Psychiatry. 1985 Aug;48(8):807-13 PubMed

Alzheimer Dis Assoc Disord. 1990 Summer;4(2):79-86 PubMed

J Neurol. 2003 Mar;250(3):371-2; author reply 372 PubMed

Adv Clin Chem. 2001;36:1-62 PubMed

J Neurol. 1980;224(2):89-99 PubMed

J Med Virol. 1986 Feb;18(2):149-58 PubMed

J Neuroimmunol. 1988 Dec;20(2-3):315-6 PubMed

Acta Neurol Scand. 2005 Aug;112(2):97-102 PubMed

J Neurol Sci. 1987 Feb;77(2-3):125-35 PubMed

Acta Neurol Scand. 1987 May;75(5):328-31 PubMed

Acta Neurol Scand. 2001 Aug;104(2):72-7 PubMed

Clin Chem Lab Med. 2003 Mar;41(3):331-7 PubMed

Sb Lek. 2003;104(1):1-12 PubMed

Folia Microbiol (Praha). 2003;48(6):849-55 PubMed

Fortschr Med. 1984 Sep 27;102(36):903-5 PubMed

Folia Microbiol (Praha). 2003;48(6):839-47 PubMed

Acta Cytol. 2001 Jan-Feb;45(1):51-9 PubMed

Acta Neurol Scand. 2000 Feb;101(2):89-94 PubMed

J Neuroimmunol. 1986 Oct;12(4):299-310 PubMed

Cryptococcal meningitis--a follow-up study of a serious clinical entity: quick cytological and microbiological diagnostics using a special staining procedure in cerebrospinal fluid specimens

Cerebrospinal fluid and serum prealbumin (transthyretin) in patients with multiple sclerosis (MS): comparison of particular subgroups of MS patients

Analysis of cerebrospinal fluid cell populations with monoclonal antibodies