Shift of oxidants and antioxidants levels in rats as a reaction to exposure to sulfur mustard
Language English Country Great Britain, England Media print
Document type Journal Article
PubMed
19533670
DOI
10.1002/jat.1451
Knihovny.cz E-resources
- MeSH
- Antioxidants analysis MeSH
- Administration, Cutaneous MeSH
- Chemical Warfare Agents toxicity MeSH
- Electrochemical Techniques MeSH
- Rats MeSH
- Oxidants blood MeSH
- Rats, Wistar MeSH
- Dose-Response Relationship, Drug MeSH
- Mustard Gas administration & dosage toxicity MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antioxidants MeSH
- Chemical Warfare Agents MeSH
- Oxidants MeSH
- Mustard Gas MeSH
Antixodants as well as oxidants levels were investigated in plasma of rats exposed to sulfur mustard in doses of 0 (control), 5, 20 and 80 mg kg(-1) body weight. Cyclic voltammetry performed on screen-printed strips with platinum working electrode used as a tool for assaying oxidant and antioxidant levels. We found significant shifts in both examined analytes. A dose of sulfur mustard of 5 mg kg(-1) body weight caused only a small change in oxidant and antioxidant levels when compared with the control group. A dose of 20 mg kg(-1) body weight provided a significant increase in antioxidants as well oxidants; however, the ratio of both was similar to that in the control group. The most surprising facts were found when the highest dose of 80 mg kg(-1) body weight of sulfur mustard was applied. While antioxidants were significantly increased, oxidants were decreased on an extensive scale.
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