Hydroxylated anthraquinones produced by Geosmithia species
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- anthrachinony chemie metabolismus farmakologie MeSH
- antibakteriální látky chemie metabolismus farmakologie MeSH
- antiflogistika nesteroidní chemie metabolismus farmakologie MeSH
- Bacillus subtilis účinky léků MeSH
- biologické pigmenty chemie metabolismus farmakologie MeSH
- biotechnologie metody MeSH
- buněčný cyklus účinky léků MeSH
- Ficus parazitologie MeSH
- HeLa buňky MeSH
- hydroxylace MeSH
- Hypocreales růst a vývoj metabolismus MeSH
- inhibitory cyklooxygenasy chemie metabolismus farmakologie MeSH
- lidé MeSH
- nosatcovití mikrobiologie fyziologie MeSH
- spory hub růst a vývoj metabolismus MeSH
- Staphylococcus aureus účinky léků MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 1-acetyl-2,4,5,7-tetrahydroxyanthraquinone MeSH Prohlížeč
- 1-acetyl-2,4,5,7,8-pentahydroxyanthraquinone MeSH Prohlížeč
- 1,3,6,8-tetrahydroxyanthraquinone MeSH Prohlížeč
- anthrachinony MeSH
- antibakteriální látky MeSH
- antiflogistika nesteroidní MeSH
- biologické pigmenty MeSH
- inhibitory cyklooxygenasy MeSH
Geosmithia fungi are little known symbionts of bark beetles. Secondary metabolites of lilac colored species G. lavendula and other nine Geosmithia species were investigated in order to elucidate their possible role in the interactions of the fungi with environment. Hydroxylated anthraquinones (yellow, orange, and red pigments), were found to be the most abundant compounds produced into the medium during the submerged cultivation. Three main compounds were identified as 1,3,6,8-tetrahydroxyanthraquinone (1), rhodolamprometrin (1-acetyl-2,4,5,7-tetrahydroxyanthraquinone; 2), and 1-acetyl-2,4,5,7,8-pentahydroxyanthraquinone (3). Compounds 2 and 3 (representing the majority of produced metabolites) inhibited the growth of G+-bacteria Staphylococcus aureus and Bacillus subtilis with minimum inhibitory concentration of 64-512 microg/mL. Anti-inflammatory activity detected as inhibition of cyclooxygenase-2 was found only for compound 3 at 1 and 10 microg/mL. Compound 2 interfered with the morphology, compound 3 with cell-cycle dynamics of adherent mammalian cell lines.
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