Biological prognostic markers in chronic lymphocytic leukemia
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- ADP-ribosyl Cyclase 1 metabolism MeSH
- Chromosome Deletion MeSH
- Leukemia, Lymphocytic, Chronic, B-Cell diagnosis genetics metabolism physiopathology MeSH
- Phosphotransferases (Alcohol Group Acceptor) metabolism MeSH
- Genes, Immunoglobulin Heavy Chain genetics MeSH
- Nuclear Proteins metabolism MeSH
- Humans MeSH
- Membrane Glycoproteins metabolism MeSH
- Neovascularization, Pathologic MeSH
- Prognosis MeSH
- RNA-Binding Proteins MeSH
- Repressor Proteins MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- ADP-ribosyl Cyclase 1 MeSH
- CD38 protein, human MeSH Browser
- Phosphotransferases (Alcohol Group Acceptor) MeSH
- Nuclear Proteins MeSH
- Membrane Glycoproteins MeSH
- RNA-Binding Proteins MeSH
- Repressor Proteins MeSH
- YLPM1 protein, human MeSH Browser
Chronic lymphocytic leukemia (CLL) is the most frequent leukemic disease of adults in the Western world. It is remarkable by an extraordinary heterogeneity of clinical course with overall survival ranging from several months to more than 15 years. Classical staging sytems by Rai and Binet, while readily available and useful for initial assessment of prognosis, are not able to determine individual patient's ongoing clinical course of CLL at the time of diagnosis, especially in early stages. Therefore, newer biological prognostic parameters are currently being clinically evaluated. Mutational status of variable region of immunoglobulin heavy chain genes (IgVH), cytogenetic aberrations, and both intracellular ZAP-70 and surface CD38 expression are recognized as parameters with established prognostic value. Molecules regulating the process of angiogenesis are also considered as promising markers. The purpose of this review is to summarize in detail the specific role of these prognostic factors in chronic lymphocytic leukemia.
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