Cardiac biomarkers in a model of acute catecholamine cardiotoxicity
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19812120
DOI
10.1177/0960327109350665
PII: 0960327109350665
Knihovny.cz E-resources
- MeSH
- Antioxidants metabolism MeSH
- Biomarkers analysis blood metabolism MeSH
- Heart Function Tests MeSH
- Myocardial Infarction blood chemically induced diagnosis metabolism MeSH
- Isoproterenol toxicity MeSH
- Catecholamines toxicity MeSH
- Blood Pressure drug effects MeSH
- Rats MeSH
- Ascorbic Acid blood MeSH
- Disease Models, Animal MeSH
- Myocardium metabolism pathology MeSH
- Rats, Wistar MeSH
- Reactive Oxygen Species metabolism MeSH
- Heart Rate drug effects MeSH
- Heart Ventricles drug effects metabolism pathology MeSH
- Troponin T blood MeSH
- Calcium metabolism MeSH
- Organ Size drug effects MeSH
- Vitamin E blood MeSH
- Iron metabolism MeSH
- Zinc metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antioxidants MeSH
- Biomarkers MeSH
- Isoproterenol MeSH
- Catecholamines MeSH
- Ascorbic Acid MeSH
- Reactive Oxygen Species MeSH
- Troponin T MeSH
- Calcium MeSH
- Vitamin E MeSH
- Iron MeSH
- Zinc MeSH
Coronary heart disease and in particular its most serious form - acute myocardial infarction (AMI) - represents the most common cause of mortality in developed countries. Better prognosis may be achieved by understanding the etiopathogenetic mechanisms of AMI. Therefore, a catecholamine model of myocardial injury, which has appeared to be very similar to AMI in human in some aspect, was used. Male Wistar:Han rats were randomly divided into two groups: control group (saline) and isoprenaline group (ISO; synthetic catecholamine, 100 mg.kg(- 1) subcutaneously [s.c.]). After 24 hours, functional parameters were measured, biochemical markers in the blood and metals content in the heart tissue were analysed and histological examination was performed. ISO caused marked myocardial injury that was associated with myocardial calcium overload. Close correlation between myocardial impairment (i.e. serum TnT, stroke volume index and wet ventricles weight) and the levels of myocardial calcium was observed. Direct reactive oxygen species (ROS) involvement was documented only by non-significant increase in malonyldialdehyde 24 hours after ISO injury. Moreover, myocardial element analysis revealed no significant changes as for the content of zinc and iron while selenium and copper increased in the ISO group although it reached statistical significance only for the latter.
References provided by Crossref.org
Comprehensive review of cardiovascular toxicity of drugs and related agents
Protective Effects of D-Penicillamine on Catecholamine-Induced Myocardial Injury
Oral administration of quercetin is unable to protect against isoproterenol cardiotoxicity
