An optimized voxel-based morphometric study of gray matter changes in patients with left-sided and right-sided mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE/HS)
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
19817822
DOI
10.1111/j.1528-1167.2009.02324.x
PII: EPI2324
Knihovny.cz E-zdroje
- MeSH
- amygdala patologie MeSH
- atrofie MeSH
- dominance mozková fyziologie MeSH
- dospělí MeSH
- epilepsie temporálního laloku diagnóza patologie MeSH
- gyrus parahippocampalis patologie MeSH
- hipokampus patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie metody MeSH
- mapování mozku metody MeSH
- mladý dospělý MeSH
- mozkový kmen patologie MeSH
- počítačové zpracování obrazu metody MeSH
- referenční hodnoty MeSH
- skleróza MeSH
- spánkový lalok patologie MeSH
- thalamus patologie MeSH
- velikost orgánu fyziologie MeSH
- zobrazování trojrozměrné metody MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
PURPOSE: To determine whether changes in gray matter volume (GMV) differ according to the affected side in mesial temporal lobe epilepsy/hippocampal sclerosis (MTLE/HS) syndrome, and moreover to test the hypothesis of more pronounced structural changes in right-sided MTLE/HS. This hypothesis (especially that the contralateral thalamus is more affected in right-sided MTLE/HS) arose from the results of our recent study, wherein more expressed structural and functional changes were observed in a small sample of patients with right-sided MTLE/HS (Brázdil et al., 2009). METHODS: Twenty patients with left-sided and 20 with right-sided MTLE/HS and 40 sex- and age-matched healthy controls were included in the study. Voxel-based morphometry (VBM) with a modulation step was applied to magnetic resonance imaging (MRI) brain images. Statistical parametric maps were used to compare structural changes between patients and controls separately for the left- and right-sided MTLE/HS subgroups. We also compared the local GMV of the brain structures (insula and thalamus) between the subgroups of patients. RESULTS: In the subgroup with right-sided MTLE/HS, a reduction of GMV was detected in the mesiotemporal structures and the ipsilateral thalamus (as in left-sided MTLE/HS), but also notably in the ipsilateral insula and contralateral thalamus. A statistical analysis revealed a significantly more extensive reduction of GMV in the ipsilateral/contralateral insula and the contralateral thalamus in the subgroup with right-sided compared to left-sided MTLE/HS. CONCLUSION: We found asymmetrical morphologic changes in patients with left- and right-sided MTLE/HS syndrome (more pronounced in right-sided MTLE/HS). These differences could be theoretically explained by different neuronal networks and pathophysiologic changes in temporolimbic structures.
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