Nucleolar transplantation in oocytes and zygotes: challenges for further research
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
19819895
DOI
10.1093/molehr/gap088
PII: gap088
Knihovny.cz E-resources
- MeSH
- Reproductive Techniques, Assisted MeSH
- Cell Nucleolus transplantation MeSH
- Embryo, Mammalian cytology MeSH
- Humans MeSH
- Oocytes cytology MeSH
- Animals MeSH
- Zygote cytology MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
In germinal vesicles of immature mammalian oocytes, including humans, as well as in pronuclei in 1-cell stage embryos, prominent nuclear organelles, nucleoli, can be easily detected even under a relatively low magnification. In humans, it has been clearly documented that their number, position and distribution in pronuclei can be used as an indicator of embryonic developmental potential. In the light of some recent experiments showing the feasibility of nucleolar manipulation we discuss here if these new approaches can be used to rescue those embryos with abnormal pronuclear nucleolar patterns.
References provided by Crossref.org
Improving the Quality of Oocytes with the Help of Nucleolotransfer Therapy
Transplantation of nucleoli into human zygotes: not as simple as expected?
