The interaction of zinc(II) and hydroxamic acids and a metal-triggered Lossen rearrangement
Language English Country Germany Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Metals chemistry MeSH
- Crystallography, X-Ray MeSH
- Hydroxamic Acids chemistry MeSH
- Ligands MeSH
- Organometallic Compounds chemistry MeSH
- Zinc chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Metals MeSH
- Hydroxamic Acids MeSH
- Ligands MeSH
- Organometallic Compounds MeSH
- Zinc MeSH
The structure and reactivity of a complex of zinc(II), water, acetic acid, and acetohydroxamic acid, in which one of the acids is deprotonated, is investigated by means of mass spectrometry, labeling studies, and density functional calculations to unravel the exceptional binding properties of hydroxamic acids towards zinc-containing enzymes at the molecular level. It is shown that acetohydroxamic acid is deprotonated in the complex, whereas acetic acid is present in its neutral form. The binding energies of the ligands towards zinc increase in the following order: water
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