The structure and reactivity of a complex of zinc(II), water, acetic acid, and acetohydroxamic acid, in which one of the acids is deprotonated, is investigated by means of mass spectrometry, labeling studies, and density functional calculations to unravel the exceptional binding properties of hydroxamic acids towards zinc-containing enzymes at the molecular level. It is shown that acetohydroxamic acid is deprotonated in the complex, whereas acetic acid is present in its neutral form. The binding energies of the ligands towards zinc increase in the following order: water

Faculty of Science Department of Organic and Nuclear Chemistry Charles University Prague Hlavova 2030 8 128 43 Prague 2 Czech Republic

Citace poskytuje Crossref.org

Monoaurated vs. diaurated intermediates: causality or independence?

Chemoselectivity in the Oxidation of Cycloalkenes with a Non-Heme Iron(IV)-Oxo-Chloride Complex: Epoxidation vs. Hydroxylation Selectivity

Characterized cis-FeV(O)(OH) intermediate mimics enzymatic oxidations in the gas phase