Porphyrin-cyclodextrin conjugates as a nanosystem for versatile drug delivery and multimodal cancer therapy
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19950899
DOI
10.1021/jm9007278
Knihovny.cz E-resources
- MeSH
- Cell Death drug effects MeSH
- Cyclodextrins chemical synthesis chemistry pharmacology MeSH
- Combined Modality Therapy MeSH
- Drug Delivery Systems * MeSH
- Humans MeSH
- Mice MeSH
- Cell Line, Tumor MeSH
- Neoplasms drug therapy pathology MeSH
- Nanotechnology * MeSH
- Porphyrins chemical synthesis chemistry pharmacology MeSH
- Antineoplastic Combined Chemotherapy Protocols chemical synthesis chemistry pharmacology MeSH
- Drug Screening Assays, Antitumor MeSH
- Structure-Activity Relationship MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cyclodextrins MeSH
- Porphyrins MeSH
The porphyrin-cyclodextrin conjugates were prepared and tested for selective and effective multifunctional drug delivery and therapy. The porphyrin receptor system combines efficient binding of the selected drug to the cyclodextrin cavity and photosensitizing properties of the porphyrin moiety with high accumulation of the whole complex in cancer tissue. The combined effect of chemotherapy and photodynamic therapy is demonstrated by in vitro and in vivo studies.
References provided by Crossref.org
Novel β-cyclodextrin-eosin conjugates
