Immunity-related gene single nucleotide polymorphisms associated with Rhodococcus equi infection in foals
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
20002811
DOI
10.1111/j.1744-313x.2009.00890.x
PII: EJI890
Knihovny.cz E-zdroje
- MeSH
- frekvence genu MeSH
- genetická predispozice k nemoci genetika MeSH
- genotyp MeSH
- imunita genetika MeSH
- infekce bakteriemi řádu Actinomycetales genetika mikrobiologie veterinární MeSH
- jednonukleotidový polymorfismus * MeSH
- koně MeSH
- nemoci koní genetika imunologie mikrobiologie MeSH
- polymorfismus délky restrikčních fragmentů MeSH
- receptory interleukinu-7 genetika MeSH
- Rhodococcus equi imunologie izolace a purifikace MeSH
- sekvenční analýza DNA MeSH
- trachea mikrobiologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- receptory interleukinu-7 MeSH
In previous work, we found significant associations of horse polymorphic microsatellite and immunity-related (IR) gene markers with Rhodococcus equi infection of foals. Here, a statistically significant association between a single nucleotide polymorphism (SNP) within the interleukin 7 receptor-encoding gene (IL7R) with high R. equi burden in transtracheal aspirates was found (Fisher's F = 0.043, odds ratio: 8.00, 95% confidence interval: 1.127-56.795). Further positional and/or functional candidate genes investigated TLR2, IL13, IL17A, IL28R, TACE/ADAM 17 and GBP1, were not associated with infection in this study. SNPs analysed were found by sequencing and appropriate restriction fragment length polymorphism markers were developed. Their associations with R. equi infection were tested by genotyping thoroughbred foals from the original study. The association was confirmed by analysing genotypes composed with genes previously reported to be associated with R. equi infection in the same group.
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