Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20027618
DOI
10.1002/dvg.20583
Knihovny.cz E-resources
- MeSH
- beta Catenin genetics metabolism MeSH
- Ectoderm metabolism MeSH
- Embryo, Mammalian metabolism MeSH
- Homeodomain Proteins genetics metabolism MeSH
- Morphogenesis genetics MeSH
- Mice, Transgenic MeSH
- Mice MeSH
- Lens, Crystalline embryology metabolism MeSH
- Eye Proteins genetics metabolism MeSH
- Wnt Proteins metabolism MeSH
- Repressor Proteins genetics metabolism MeSH
- Retina metabolism MeSH
- Signal Transduction genetics MeSH
- PAX6 Transcription Factor MeSH
- Paired Box Transcription Factors genetics metabolism MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- beta Catenin MeSH
- Homeodomain Proteins MeSH
- Eye Proteins MeSH
- Pax6 protein, mouse MeSH Browser
- Wnt Proteins MeSH
- Repressor Proteins MeSH
- PAX6 Transcription Factor MeSH
- Paired Box Transcription Factors MeSH
Lens formation in mouse is critically dependent on proper development of the retinal neuroectoderm that is located close beneath the head surface ectoderm. Signaling from the prospective retina triggers lens-specific gene expression in the surface-ectoderm. Supression of canonical Wnt/beta-catenin signaling in the surface ectoderm is one of the prerequisites for lens development because, as we show here, ectopic Wnt activation in the retina and lens abrogates lens formation. Wnt inhibiton is mediated by signals coming from the retina but its exact mechanism is unknown. We show that Pax6 directly controls expression of several Wnt inhibitors such as Sfrp1, Sfrp2, and Dkk1 in the presumptive lens. In accordance, absence of Pax6 function leads to aberrant canonical Wnt activity in the presumptive lens that subsequently impairs lens development. Thus Pax6 is required for down-regulation of canonical Wnt signaling in the presumptive lens ectoderm.
References provided by Crossref.org
WNT/β-Catenin Signaling in Vertebrate Eye Development
