Two cases of severe invasive infections in children caused by Streptococcus pneumoniae serotype 14--case report
Language English Country United States Media print-electronic
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Anti-Bacterial Agents therapeutic use MeSH
- Child MeSH
- Fatal Outcome MeSH
- Immunocompromised Host MeSH
- Infant MeSH
- Humans MeSH
- Meningitis, Bacterial diagnosis microbiology pathology MeSH
- Otitis Media complications MeSH
- Pneumococcal Infections diagnosis microbiology pathology MeSH
- Pneumonia, Pneumococcal diagnosis microbiology pathology MeSH
- Penicillin Resistance MeSH
- Serotyping MeSH
- Streptococcus pneumoniae classification isolation & purification MeSH
- Bacterial Typing Techniques MeSH
- Check Tag
- Child MeSH
- Infant MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
Two cases are presented of severe pneumococcal infections in infants caused by serotype 14 Streptococcus pneumoniae. The first case--meningitis--caused by S. pneumoniae (pneumococcus) with low-level penicillin susceptibility has developed from acute otitis media and resulted in fatal outcome. The second one--an immunocompromised child presenting recurrent otitis and chronic mastoiditis--developed into pneumococcal pneumonia. Both cases demonstrate the extreme importance of a relevant initial treatment of localized pneumococcal infections, preventing the development of generalized infection. Amoxicillin (an oral treatment option in both upper and lower respiratory tract infections caused also by Pneumococcus strains with low-level penicillin susceptibility due to its beneficial pharmacokinetics and pharmacodynamics) was not used in either case.
See more in PubMed
BMJ. 2009 Jun 23;338:b2242 PubMed
Bratisl Lek Listy. 1983 Aug;80(2):176-84 PubMed
J Infect Dis. 1995 Jun;171(6):1491-6 PubMed
Bratisl Lek Listy. 1999 Nov;100(11):587-92 PubMed
JAMA. 2006 Sep 13;296(10):1235-41 PubMed
J Infect Dis. 2003 May 1;187(9):1424-32 PubMed
Microb Drug Resist. 1995 Spring;1(1):71-8 PubMed
J Infect Dis. 1996 Feb;173(2):374-9 PubMed
Pediatrics. 2004 May;113(5):1451-65 PubMed
J Antimicrob Chemother. 2007 Aug;60(2):323-7 PubMed
Eur J Pediatr. 2006 May;165(5):283-4 PubMed
