Uterine tumors with neuroectodermal differentiation. A report of 4 cases
Jazyk angličtina Země Švýcarsko Médium print-electronic
Typ dokumentu kazuistiky, časopisecké články, práce podpořená grantem
- MeSH
- buněčná diferenciace fyziologie MeSH
- genová přestavba MeSH
- imunohistochemie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory dělohy genetika patologie MeSH
- neuroektodermové nádory genetika patologie MeSH
- protein EWS vázající RNA MeSH
- proteiny vázající kalmodulin genetika MeSH
- proteiny vázající RNA genetika MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- práce podpořená grantem MeSH
- Názvy látek
- EWSR1 protein, human MeSH Prohlížeč
- protein EWS vázající RNA MeSH
- proteiny vázající kalmodulin MeSH
- proteiny vázající RNA MeSH
We report four cases of uterine tumors with neuroectodermal differentiation. One tumor had neuroectodermal component only; in the three other tumors, the neuroectodermal component was admixed with another component, namely rhabdomyosarcoma (1 case), and endometrioid adenocarcinoma (2 cases). Histologically, the neuroectodermal component consisted of small to medium sized cells arranged in diffuse sheets. The tumor cells had round nuclei with stippled to coarsely granular chromatin, mostly with non-prominent nucleoli, and scant eosinophilic or amphophilic cytoplasm. Immunohistochemically, 4/4 tumors showed expression of vimentin, synaptophysin and CD56; 3/4 tumors were CD99 and NSE positive; 2/4 tumors showed focal expression of S-100 protein; and 1/4 tumors had focal dot-like cytoplasmic positivity for cytokeratin AE1/AE3. FLI-1 was negative in all cases. FISH examination was performed and none of the tumors showed rearrangement of EWSR1 gene. Uterine tumors with neuroectodermal differentiation are rare; to the best of our knowledge only 44 cases have been reported in the literature to date, referred to as Ewing sarcoma, peripheral PNET (pPNET), PNET (not otherwise specified) and uterine tumors with neuroendocrine differentiation.
Zobrazit více v PubMed
Int J Gynecol Pathol. 2000 Apr;19(2):127-32 PubMed
J Obstet Gynaecol. 2009 Jan;29(1):73-4 PubMed
Cesk Patol. 2008 Jul;44(3):67-70 PubMed
Obstet Gynecol. 2000 Nov;96(5 Pt 2):832-4 PubMed
Histopathology. 2006 Dec;49(6):569-75 PubMed
Int J Gynecol Pathol. 1989;8(2):169-78 PubMed
Arch Anat Cytol Pathol. 1992;40(2-3):158-9 PubMed
Gynecol Oncol. 2004 Feb;92(2):689-96 PubMed
Hum Pathol. 1992 Oct;23(10):1120-9 PubMed
Am J Surg Pathol. 1994 May;18(5):486-94 PubMed
Gynecol Oncol. 2007 Aug;106(2):427-32 PubMed
Eur J Obstet Gynecol Reprod Biol. 1998 Feb;76(2):181-4 PubMed
Pediatr Blood Cancer. 2005 Mar;44(3):283-5 PubMed
Acta Cytol. 2000 Jul-Aug;44(4):667-72 PubMed
Histopathology. 1992 Dec;21(6):584-5 PubMed
Reprod Sci. 2009 Jun;16(6):591-5 PubMed
Int J Gynecol Pathol. 2006 Oct;25(4):373-7 PubMed
Arch Gynecol Obstet. 2009 Feb;279(2):259-61 PubMed
Arch Pathol Lab Med. 1990 Jan;114(1):101-5 PubMed
Eur J Gynaecol Oncol. 2004;25(3):384-6 PubMed
Am J Surg Pathol. 2000 Mar;24(3):410-6 PubMed
Am J Clin Pathol. 1994 Nov;102(5):692-4 PubMed
Mod Pathol. 2004 May;17(5):547-52 PubMed
Arch Gynecol Obstet. 2008 Apr;277(4):345-8 PubMed
J Reprod Med. 2001 Sep;46(9):845-8 PubMed
Histopathology. 1998 Oct;33(4):369-74 PubMed
Am J Surg Pathol. 1981 Oct;5(7):695-9 PubMed
Zentralbl Gynakol. 1994;116(10):577-80 PubMed
Pathology. 2002 Oct;34(5):455-61 PubMed
J Surg Oncol. 1987 Jul;35(3):165-9 PubMed
N Engl J Med. 1994 Aug 4;331(5):294-9 PubMed
J Comput Assist Tomogr. 1998 Nov-Dec;22(6):896-8 PubMed
Gynecol Oncol. 2007 Aug;106(2):419-22 PubMed
Am J Surg Pathol. 2008 Feb;32(2):219-28 PubMed
Histopathology. 1997 May;30(5):483-5 PubMed
Tohoku J Exp Med. 1996 Oct;180(2):187-95 PubMed
Hum Pathol. 2007 Feb;38(2):205-11 PubMed
Histopathology. 1996 Dec;29(6):565-70 PubMed
Semin Diagn Pathol. 2000 Aug;17(3):194-203 PubMed
Int J Gynecol Cancer. 2007 Mar-Apr;17(2):524-7 PubMed
Am J Surg Pathol. 1998 Nov;22(11):1417-22 PubMed
