Cognitive impairment and structural brain changes in patients with clinically isolated syndrome at high risk for multiple sclerosis
Language English Country Germany Media print-electronic
Document type Journal Article
PubMed
28028623
DOI
10.1007/s00415-016-8368-9
PII: 10.1007/s00415-016-8368-9
Knihovny.cz E-resources
- Keywords
- Clinically isolated syndrome, Cognition, MRI, Multiple sclerosis, Neuropsychology, Voxel-based morphometry,
- MeSH
- Atrophy MeSH
- Demyelinating Diseases complications diagnostic imaging psychology MeSH
- Adult MeSH
- Cognitive Dysfunction diagnostic imaging etiology MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Brain diagnostic imaging MeSH
- Neuropsychological Tests MeSH
- Image Processing, Computer-Assisted MeSH
- Disability Evaluation MeSH
- Prognosis MeSH
- Disease Progression MeSH
- Risk Factors MeSH
- Organ Size MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
Patients with clinically isolated syndrome (CIS), unlike those with multiple sclerosis (MS), have a selective cognitive impairment which is not consistently related to structural brain changes. Our objective was to characterize a profile of cognitive impairment and its association with structural brain changes in patients with CIS who are at high risk of developing MS. Patients with CIS at high risk for MS on interferon-beta (n = 51) and age-, gender-, and education-matched controls (n = 44) underwent comprehensive neuropsychological testing and MRI brain scan with voxel-based morphometry. The CIS group had lower cognitive performance in verbal and nonverbal memory, information processing speed/attention/working memory, and executive and visuo-spatial functions compared to controls (p ≤ 0.040). Lower cognitive performance was present in 18-37 and 14-26% of patients with CIS at high risk for MS depending on the criteria used. Brain volume was reduced predominantly in fronto-temporal regions and the thalamus in the CIS group (p ≤ 0.019). Cognitive performance was not associated with structural brain changes except for the association between worse visuo-spatial performance and lower white matter volume in the CIS group (β = 0.29; p = 0.042). Our results indicated that patients with CIS at high risk for MS may have a pattern of lower cognitive performance and regional brain atrophy similar to that found in patients with MS. Lower cognitive performance may be present in up to one-third of patients with CIS at high risk for MS, but, unlike patients with MS, variability in their cognitive performance may lead to a lack of consistent associations with structural brain changes.
See more in PubMed
Alzheimer Dis Assoc Disord. 2009 Apr-Jun;23(2):91-101 PubMed
J Neurol Sci. 2008 Apr 15;267(1-2):100-6 PubMed
Mult Scler. 2005 Oct;11(5):524-31 PubMed
Neuroimage. 2007 Jul 15;36(4):1294-300 PubMed
Percept Mot Skills. 1977 Apr;44(2):367-73 PubMed
Hum Brain Mapp. 2012 Sep;33(9):2062-71 PubMed
Eur Neurol. 2012;68(1):23-7 PubMed
Neurology. 2010 Jan 26;74(4):321-8 PubMed
Mult Scler. 2013 Aug;19(9):1122-7 PubMed
Arch Neurol. 2007 Aug;64(8):1157-61 PubMed
Brain Imaging Behav. 2014 Sep;8(3):378-86 PubMed
Mult Scler. 2006 Aug;12(4):428-36 PubMed
Arch Neurol. 2006 Sep;63(9):1301-6 PubMed
J Consult Clin Psychol. 1988 Dec;56(6):893-7 PubMed
Neuroradiology. 2001 Apr;43(4):272-8 PubMed
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2014;21(6):693-721 PubMed
Ann Neurol. 2011 Feb;69(2):292-302 PubMed
J Neurol. 2012 Jan;259(1):139-46 PubMed
Brain. 2008 Mar;131(Pt 3):808-17 PubMed
Mult Scler. 2014 Jan;20(1):72-80 PubMed
J Neurol Neurosurg Psychiatry. 2003 Apr;74(4):443-6 PubMed
Brain. 2000 Sep;123 ( Pt 9):1845-9 PubMed
J Neurol Neurosurg Psychiatry. 2008 Aug;79(8):955-8 PubMed
Lancet Neurol. 2008 Dec;7(12):1139-51 PubMed
Mult Scler. 2001 Dec;7(6):359-63 PubMed
Mult Scler. 2012 Oct;18(10):1466-71 PubMed
J Intern Med. 2004 Sep;256(3):183-94 PubMed
Mod Probl Pharmacopsychiatry. 1974;7(0):151-69 PubMed
Mult Scler. 2007 Sep;13(8):1004-10 PubMed
J Neurol Sci. 2014 Jul 15;342(1-2):62-8 PubMed
Swiss Med Wkly. 2007 Sep 8;137(35-36):496-501 PubMed
Mult Scler. 2007 Jan;13(1):124-7 PubMed
J Neurol Neurosurg Psychiatry. 2008 Nov;79(11):1236-44 PubMed
Mult Scler. 2015 Aug;21(9):1151-8 PubMed
J Neurol. 2014 Sep;261(9):1735-44 PubMed
Neuroimage. 2002 Sep;17(1):479-89 PubMed
Neurology. 1994 Apr;44(4):635-41 PubMed
Neuroimage. 2014 May 15;92:381-97 PubMed
Epilepsia. 2011 Jun;52(6):1186-91 PubMed
AJNR Am J Neuroradiol. 2012 Sep;33(8):1573-8 PubMed
Behav Neurol. 2012;25(4):311-26 PubMed
J Neurol Neurosurg Psychiatry. 2010 Jun;81(6):690-5 PubMed
J Neurol Sci. 2013 Jul 15;330(1-2):56-60 PubMed
AJNR Am J Neuroradiol. 2005 Aug;26(7):1824-31 PubMed
AJNR Am J Neuroradiol. 1999 Nov-Dec;20(10):1951-5 PubMed
Brain. 2015 Jul;138(Pt 7):1863-74 PubMed
PLoS One. 2012;7(5):e37049 PubMed
Arch Neurol. 2009 Sep;66(9):1144-50 PubMed
J Neurol Neurosurg Psychiatry. 2009 Feb;80(2):201-6 PubMed
Arch Clin Neuropsychol. 2012 Dec;27(8):906-14 PubMed
Mult Scler. 2011 Feb;17(2):173-80 PubMed
Eur J Neurol. 2008 Oct;15(10):1091-9 PubMed
Spatial navigation in early multiple sclerosis: a neglected cognitive marker of the disease?
Cognitive clinico-radiological paradox in early stages of multiple sclerosis
