Corpus callosum atrophy--a simple predictor of multiple sclerosis progression: a longitudinal 9-year study
Language English Country Switzerland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
22677920
DOI
10.1159/000337683
PII: 000337683
Knihovny.cz E-resources
- MeSH
- Atrophy pathology MeSH
- Corpus Callosum pathology MeSH
- Adult MeSH
- Humans MeSH
- Longitudinal Studies MeSH
- Magnetic Resonance Imaging MeSH
- Disease Progression MeSH
- Multiple Sclerosis, Relapsing-Remitting pathology MeSH
- Retrospective Studies MeSH
- Sensitivity and Specificity MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
AIM: To determine whether corpus callosum atrophy predicts future clinical deterioration in multiple sclerosis. METHODS: In 39 multiple sclerosis patients the area of corpus callosum in the sagittal plane, T2 and T1 lesion volumes, brain parenchymal fraction and brain atrophy were determined at baseline and 1 year after treatment initiation. Non-parametric and multiple regression models were built to identify the most reliable predictors of disability and of its changes over 9 years. RESULTS: Corpus callosum atrophy during the first year of treatment was the best predictor of disability (r = -0.56) and of its increase at 9 years (r = 0.65). Corpus callosum atrophy of at least 2% predicted increase in disability with 93% sensitivity and 73% specificity (odds ratio = 35). CONCLUSION: Corpus callosum atrophy is a simple and accurate predictor of future disability accumulation and is feasible for routine clinical practice.
References provided by Crossref.org
Thalamic Iron Differentiates Primary-Progressive and Relapsing-Remitting Multiple Sclerosis
