Probiotika u akutni pankreatitidy--randomizovaná, placebem kontrolovaná, dvojitĕ slepá studie
[Probiotics in acute pancreatitis--a randomised, placebo-controlled, double-blind study]
Jazyk čeština Země Česko Médium print
Typ dokumentu anglický abstrakt, časopisecké články, randomizované kontrolované studie
PubMed
20329580
- MeSH
- akutní nemoc MeSH
- bakteriální infekce komplikace prevence a kontrola MeSH
- dvojitá slepá metoda MeSH
- endotoxiny krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- pankreatitida krev komplikace MeSH
- probiotika terapeutické užití MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
- Názvy látek
- endotoxiny MeSH
INTRODUCTION: Infections accompanying pancreatitis, particularly pancreatic necroses, represent a serious complication associated with worsening of the disease prognosis. The aim of our study was to explore whether this complication could be prevented by administering a probiotic. METHODS: The probiotic was administered to 7 patients and placebo to 15. The study was discontinued early following the release of the Propatria study results. RESULTS: There was no death in our patient sample and there was no difference between the two groups in microbial colonisation or the length of hospitalization. However, a reduction in endotoxin levels on day 7 and 10 of the hospitalization was observed in the probiotic-treated group. CONCLUSION: Based on the current knowledge, administration of probiotics in this indication is contraindicated. Nonetheless, reduction in endotoxin levels suggests a positive effect of probiotics on bacterial translocation, the importance of which should be evaluated in the future.
