Two case reports of columnar dyskeratosis, an unusual keratinisation disorder
Language English Country Switzerland Media print-electronic
Document type Case Reports, Journal Article
PubMed
20332594
DOI
10.1159/000283093
PII: 000283093
Knihovny.cz E-resources
- MeSH
- Keratosis diagnosis pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
Keratinisation disorders with distinctive histopathological patterns are few in number. We describe two men with unusual dermatosis, characterised by a distinctive pattern of focal dyskeratosis. Both men suffered from generalised dermatosis formed by verrucous red-brown plaques. Repeated skin biopsies showed the same histopathological pattern with foci of vertically oriented dyskeratotic cells. The dyskeratotic cells on the level of the stratum spinosum and granulosum were positive for AE1/AE3, CK-HW, CK-LS and CK116 immunostaining. PCR for HPV was negative. The similar clinical appearance of skin lesions in both patients together with their identical histopathological pictures seems to represent a unique clinicopathological condition that we believe is best described by the term 'columnar dyskeratosis'.
References provided by Crossref.org
Human polyomavirus 6 and 7 are associated with pruritic and dyskeratotic dermatoses