Interaction of nerve agent antidotes with cholinergic systems
Jazyk angličtina Země Spojené arabské emiráty Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
20345348
DOI
10.2174/092986710791111260
PII: BSP/CMC/E-Pub/102
Knihovny.cz E-zdroje
- MeSH
- acetylcholin metabolismus MeSH
- antidota chemie metabolismus farmakologie MeSH
- chemické bojové látky * otrava MeSH
- cholinesterasy metabolismus MeSH
- lidé MeSH
- organofosforové sloučeniny antagonisté a inhibitory MeSH
- otrava organofosfáty MeSH
- receptory cholinergní metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- acetylcholin MeSH
- antidota MeSH
- chemické bojové látky * MeSH
- cholinesterasy MeSH
- organofosforové sloučeniny MeSH
- receptory cholinergní MeSH
The poisoning with organophosphorus compounds represents a life threatening danger especially in the time of terroristic menace. No universal antidote has been developed yet and other therapeutic approaches not related to reactivation of acetylcholinesterase are being investigated. This review describes the main features of the cholinergic system, cholinergic receptors, cholinesterases and their inhibitors. It also focuses on the organophosphorus nerve agents, their properties, effects and a large part describes various possibilities in treatments, mainly traditional oxime therapies based on reactivation of AChE. Furthermore, non-cholinesterase coupled antidotal effects of the oximes are thoroughly discussed. These antidotal effects principally include oxime interactions with muscarinic and nicotinic receptors.
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