Transkarbams as transdermal permeation enhancers: effects of ester position and ammonium carbamate formation
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20381349
DOI
10.1016/j.bmcl.2010.03.077
PII: S0960-894X(10)00408-7
Knihovny.cz E-resources
- MeSH
- Administration, Cutaneous MeSH
- Esters MeSH
- Carbamates administration & dosage chemical synthesis chemistry MeSH
- Skin drug effects MeSH
- Permeability drug effects MeSH
- Swine MeSH
- Drug Delivery Systems MeSH
- Structure-Activity Relationship MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- carbamic acid MeSH Browser
- Esters MeSH
- Carbamates MeSH
- transkarbam 12 MeSH Browser
Transkarbam 12, an ammonium carbamate formed by the reaction of dodecyl 6-aminohexanoate with carbon dioxide, is a highly active, broad-spectrum, nontoxic, and nonirritant transdermal permeation enhancer. It probably acts by a dual mechanism: a part of its activity is associated with the carbamic acid salt and/or its decomposition in the acidic stratum corneum. The ammonium ester thereby released is an active enhancer species as well, and its activity highly depends on the position of the ester group.
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