Synergistic action of doxorubicin bound to the polymeric carrier based on N-(2-hydroxypropyl)methacrylamide copolymers through an amide or hydrazone bond
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20524698
DOI
10.1021/mp100121g
Knihovny.cz E-resources
- MeSH
- Acrylamides chemistry MeSH
- Amides chemistry MeSH
- Cell Line MeSH
- Doxorubicin chemistry pharmacology MeSH
- Microscopy, Fluorescence MeSH
- Hydrazones chemistry MeSH
- Humans MeSH
- Lymphoma, T-Cell drug therapy MeSH
- Molecular Structure MeSH
- Mice, Inbred C57BL MeSH
- Mice, Nude MeSH
- Mice MeSH
- Cell Line, Tumor MeSH
- Polymers chemical synthesis chemistry MeSH
- Antibiotics, Antineoplastic chemistry pharmacology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Acrylamides MeSH
- Amides MeSH
- Doxorubicin MeSH
- Hydrazones MeSH
- N-(2-hydroxypropyl)methacrylamide MeSH Browser
- Polymers MeSH
- Antibiotics, Antineoplastic MeSH
The cytostatic effects of polymeric conjugates based on N-(2-hydroxypropyl)methacrylamide copolymers (PHPMA) and containing doxorubicin bound through amide and hydrazone bonds (mixed conjugates) were compared with the cytostatic effects of monoconjugates containing drug bound through an amide or hydrazone bond. One group of mixed conjugates was formed from two comonomers containing doxorubicin bound to the methacryloyl group through a spacer and an amide (DOX(AM)) or hydrazone (DOX(HYD)) bond via copolymerization with HPMA. A second group of mixed conjugates was formed from two different interconnected HPMA copolymers, one containing DOX(AM) and the other DOX(HYD), forming a high-molecular-weight branched structure. The third mixed polymeric system was a simple mixture of monoconjugates DOX(AM)-PHPMA and DOX(HYD)-PHPMA. Simultaneous treatment with all mixed forms of the polymeric derivatives of doxorubicin significantly increased antitumor efficacy after application of monoconjugates, suggesting a synergizing effect that could be used in designing new doxorubicin-containing therapeutic systems.
References provided by Crossref.org
HPMA Copolymer-Based Nanomedicines in Controlled Drug Delivery
