Biochemical and physiological responses in liver and muscle of rainbow trout after long-term exposure to propiconazole
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
20621356
DOI
10.1016/j.ecoenv.2010.05.017
PII: S0147-6513(10)00104-1
Knihovny.cz E-zdroje
- MeSH
- časové faktory MeSH
- chemické látky znečišťující vodu toxicita MeSH
- DNA metabolismus MeSH
- játra účinky léků enzymologie fyziologie MeSH
- katalasa metabolismus MeSH
- kosterní svaly účinky léků enzymologie fyziologie MeSH
- Oncorhynchus mykiss * metabolismus fyziologie MeSH
- reaktivní formy kyslíku metabolismus MeSH
- RNA metabolismus MeSH
- superoxiddismutasa metabolismus MeSH
- triazoly toxicita MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- chemické látky znečišťující vodu MeSH
- DNA MeSH
- katalasa MeSH
- propiconazole MeSH Prohlížeč
- reaktivní formy kyslíku MeSH
- RNA MeSH
- superoxiddismutasa MeSH
- triazoly MeSH
In this study, the chronic toxic effects of PCZ, a triazole fungicide commonly present in surface and ground water, on morphological indices, ROS generation and RNA/DNA ratio in liver and white muscle of rainbow trout were investigated. Fish were exposed at sublethal concentrations of PCZ (0.2, 50 and 500 microg L(-1)) for 7, 20 and 30d. Compared with the control, there were significant lower CF and HSI in fish exposed at the highest concentration of PCZ. ROS levels in both tissues increased significantly at higher PCZ concentrations (50 and 500 microg L(-1)) after 20 d and above, as well as in muscle of fish exposed at lowest PCZ concentration (0.2 microg L(-1)) after 30 d. The hepatic antioxidant enzymes (SOD and CAT) activities were induced significantly at higher concentrations (50, 500 microg L(-1)) of PCZ after 20 d and at 50 microg L(-1) after 30 d. Additional, hepatic SOD activity was significantly induced at 0.2 microg L(-1) after 30 d. Compared with the hepatic antioxidant enzymes activities in fish exposed to 50 microg L(-1) of PCZ, there was a decreasing trend in those exposed to 500 microg L(-1) after 30 d exposure. However, both the antioxidant enzymes activities were significantly inhibited in muscle of fish exposed to 500 microg L(-1) PCZ after 30 d. Moreover there was significant lower RNA/DNA ratio in both tissues after long-term exposure to higher concentration of PCZ. In short, environmental concentrations of PCZ could not induce obvious impacts on fish, but long-term exposure to higher concentrations of CBZ could affect seriously the health status of fish.
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