Biochemical and physiological responses in liver and muscle of rainbow trout after long-term exposure to propiconazole
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
20621356
DOI
10.1016/j.ecoenv.2010.05.017
PII: S0147-6513(10)00104-1
Knihovny.cz E-resources
- MeSH
- Time Factors MeSH
- Water Pollutants, Chemical toxicity MeSH
- DNA metabolism MeSH
- Liver drug effects enzymology physiology MeSH
- Catalase metabolism MeSH
- Muscle, Skeletal drug effects enzymology physiology MeSH
- Oncorhynchus mykiss * metabolism physiology MeSH
- Reactive Oxygen Species metabolism MeSH
- RNA metabolism MeSH
- Superoxide Dismutase metabolism MeSH
- Triazoles toxicity MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Water Pollutants, Chemical MeSH
- DNA MeSH
- Catalase MeSH
- propiconazole MeSH Browser
- Reactive Oxygen Species MeSH
- RNA MeSH
- Superoxide Dismutase MeSH
- Triazoles MeSH
In this study, the chronic toxic effects of PCZ, a triazole fungicide commonly present in surface and ground water, on morphological indices, ROS generation and RNA/DNA ratio in liver and white muscle of rainbow trout were investigated. Fish were exposed at sublethal concentrations of PCZ (0.2, 50 and 500 microg L(-1)) for 7, 20 and 30d. Compared with the control, there were significant lower CF and HSI in fish exposed at the highest concentration of PCZ. ROS levels in both tissues increased significantly at higher PCZ concentrations (50 and 500 microg L(-1)) after 20 d and above, as well as in muscle of fish exposed at lowest PCZ concentration (0.2 microg L(-1)) after 30 d. The hepatic antioxidant enzymes (SOD and CAT) activities were induced significantly at higher concentrations (50, 500 microg L(-1)) of PCZ after 20 d and at 50 microg L(-1) after 30 d. Additional, hepatic SOD activity was significantly induced at 0.2 microg L(-1) after 30 d. Compared with the hepatic antioxidant enzymes activities in fish exposed to 50 microg L(-1) of PCZ, there was a decreasing trend in those exposed to 500 microg L(-1) after 30 d exposure. However, both the antioxidant enzymes activities were significantly inhibited in muscle of fish exposed to 500 microg L(-1) PCZ after 30 d. Moreover there was significant lower RNA/DNA ratio in both tissues after long-term exposure to higher concentration of PCZ. In short, environmental concentrations of PCZ could not induce obvious impacts on fish, but long-term exposure to higher concentrations of CBZ could affect seriously the health status of fish.
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