A comparison of the ability of newly-developed bispyridinium oxime K203 and currently available oximes (trimedoxime, obidoxime, HI-6) to counteract the acute neurotoxicity of soman in rats
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
- MeSH
- atropin farmakologie MeSH
- chemické bojové látky toxicita MeSH
- chování zvířat účinky léků fyziologie MeSH
- kombinovaná farmakoterapie MeSH
- krysa rodu Rattus MeSH
- neuroprotektivní látky farmakologie MeSH
- neurotoxické syndromy farmakoterapie patofyziologie MeSH
- oximy farmakologie MeSH
- pohybová aktivita účinky léků fyziologie MeSH
- potkani Wistar MeSH
- pyridinové sloučeniny farmakologie MeSH
- soman toxicita MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- 1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene MeSH Prohlížeč
- asoxime chloride MeSH Prohlížeč
- atropin MeSH
- chemické bojové látky MeSH
- neuroprotektivní látky MeSH
- oximy MeSH
- pyridinové sloučeniny MeSH
- soman MeSH
The neuroprotective effects of newly-developed oxime K203 and currently available oximes (trimedoxime, obidoxime, HI-6) in combination with atropine in rats poisoned with soman were studied. The soman-induced neurotoxicity was monitored using a functional observational battery at 24 h following soman challenge. The results indicate that the potency of a newly-developed oxime K203 to counteract soman-induced neurotoxicity is very low and roughly corresponds to the neuroprotective efficacy of currently available oximes. Among tested oximes, the oxime HI-6 seems to be the most efficacious to counteract acute neurotoxicity of soman, although the differences in neuroprotective efficacy of chosen oximes are not significant. Thus, the oxime K203 does not provide any beneficial effect for the antidotal treatment of acute poisoning with soman and the oxime HI-6 should be still considered to be the best oxime for antidotal treatment of acute soman poisonings.
Citace poskytuje Crossref.org
