A comparison of the ability of newly-developed bispyridinium oxime K203 and currently available oximes (trimedoxime, obidoxime, HI-6) to counteract the acute neurotoxicity of soman in rats
Language English Country England, Great Britain Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Atropine pharmacology MeSH
- Chemical Warfare Agents toxicity MeSH
- Behavior, Animal drug effects physiology MeSH
- Drug Therapy, Combination MeSH
- Rats MeSH
- Neuroprotective Agents pharmacology MeSH
- Neurotoxicity Syndromes drug therapy physiopathology MeSH
- Oximes pharmacology MeSH
- Motor Activity drug effects physiology MeSH
- Rats, Wistar MeSH
- Pyridinium Compounds pharmacology MeSH
- Soman toxicity MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- 1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene MeSH Browser
- asoxime chloride MeSH Browser
- Atropine MeSH
- Chemical Warfare Agents MeSH
- Neuroprotective Agents MeSH
- Oximes MeSH
- Pyridinium Compounds MeSH
- Soman MeSH
The neuroprotective effects of newly-developed oxime K203 and currently available oximes (trimedoxime, obidoxime, HI-6) in combination with atropine in rats poisoned with soman were studied. The soman-induced neurotoxicity was monitored using a functional observational battery at 24 h following soman challenge. The results indicate that the potency of a newly-developed oxime K203 to counteract soman-induced neurotoxicity is very low and roughly corresponds to the neuroprotective efficacy of currently available oximes. Among tested oximes, the oxime HI-6 seems to be the most efficacious to counteract acute neurotoxicity of soman, although the differences in neuroprotective efficacy of chosen oximes are not significant. Thus, the oxime K203 does not provide any beneficial effect for the antidotal treatment of acute poisoning with soman and the oxime HI-6 should be still considered to be the best oxime for antidotal treatment of acute soman poisonings.
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