Potentiation of adenosinergic inhibitory modulation is one of possible strategies to develop new antiepileptic drugs. Nonspecific receptor agonist 2-chloroadenosine was tested against pentetrazol-induced convulsions in immature (7, 12, 18 and 25 days old) and adult rats. Doses of 1-15 mg/kg i.p. suppressed tonic phase of generalized tonic-clonic seizures (GTCS) in the two youngest groups, whereas GTCS were abolished in older rats. Minimal clonic seizures in 18-day and older rats were suppressed by high doses of 2-chloroadenosine. The role of A1 and A2A adenosine receptors was studied in 12- and 25-day-old rats. Action of an agonist of A1 receptors CCPA is similar to that of 2-chloroadenosine. An agonist of A2A receptors CGS 21680 exhibits an anticonvulsant action only in the dose-inducing catalepsy; an A2A antagonist ZM 241385 moderately suppressed tonic phase of GTCS only in 12-day-old animals. Anticonvulsant action of adenosine agonists is due to their effects on A1 receptors.

Department of Developmental Epileptology Institute of Physiology Academy of Sciences of the Czech Republic Videnska 1083 14220 Prague 4 Czech Republic

Zobrazit více v PubMed

Life Sci. 1992;50(22):1665-72 PubMed

Eur J Neurosci. 2003 Aug;18(4):820-8 PubMed

Naunyn Schmiedebergs Arch Pharmacol. 1992 Nov;346(5):588-91 PubMed

Neuron Glia Biol. 2007 Nov;3(4):353-66 PubMed

Brain Dev. 1994 Jul-Aug;16(4):296-300 PubMed

Epilepsy Res. 2001 May;44(2-3):89-96 PubMed

Life Sci. 1985 Dec 9;37(23):2205-11 PubMed

Pharmacol Rep. 2010 Jan-Feb;62(1):62-7 PubMed

J Neurochem. 1987 Sep;49(3):852-5 PubMed

Neuroscientist. 2005 Feb;11(1):25-36 PubMed

Pharmacol Biochem Behav. 1990 Aug;36(4):751-5 PubMed

J Neurochem. 1982 Jul;39(1):267-70 PubMed

Eur J Pharmacol. 1997 May 12;326(1):7-14 PubMed

Ann Neurol. 1992 Nov;32(5):618-24 PubMed

Eur J Neurosci. 2004 May;19(9):2539-50 PubMed

Brain Res. 1985 Dec 30;361(1-2):309-23 PubMed

J Clin Invest. 2008 Feb;118(2):571-82 PubMed

Pol J Pharmacol Pharm. 1987 Sep-Oct;39(5):537-43 PubMed

Physiol Res. 2008;57(6):969-972 PubMed

Epilepsy Res. 2000 May;39(3):183-90 PubMed

Brain Res. 2006 Apr 12;1082(1):43-9 PubMed

Brain Res Dev Brain Res. 1998 Sep 10;110(1):51-9 PubMed

Brain Res. 1984 Mar;315(1):97-104 PubMed

Brain Res Dev Brain Res. 1995 Oct 27;89(1):124-8 PubMed

Epilepsy Res. 2004 Apr-May;59(2-3):83-94 PubMed

Annu Rev Pharmacol Toxicol. 2005;45:385-412 PubMed

Handb Exp Pharmacol. 2009;(193):535-87 PubMed

Brain Res Dev Brain Res. 1989 Apr 1;46(2):169-72 PubMed

Physiol Res. 2008;57(5):789-792 PubMed

Epilepsia. 1989 Jul-Aug;30(4):501-10 PubMed

Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):375-81 PubMed

Neurosci Res. 2006 Sep;56(1):14-20 PubMed

Prog Neurobiol. 1988;31(2):85-108 PubMed

Epilepsia. 1993 May-Jun;34(3):453-68 PubMed

Epilepsia. 1995 Aug;36(8):763-71 PubMed

Physiol Bohemoslov. 1981;30(2):113-21 PubMed

Epilepsy Res. 1991 Nov-Dec;10(2-3):148-55 PubMed

Psychopharmacology (Berl). 2003 Jul;168(3):299-306 PubMed

Psychopharmacology (Berl). 1994 Jul;115(3):320-4 PubMed

Epilepsy Res. 1994 May;18(1):29-42 PubMed

Int Rev Neurobiol. 2005;63:191-270 PubMed

Eur J Pharmacol. 1996 Apr 22;301(1-3):107-13 PubMed

Brain Res. 2007 May 30;1150:32-9 PubMed

Epilepsy Res. 1988 May-Jun;2(3):145-81 PubMed

Pharmacol Biochem Behav. 2008 May;89(3):345-51 PubMed

Annu Rev Neurosci. 2001;24:31-55 PubMed

Curr Opin Pharmacol. 2008 Feb;8(1):2-7 PubMed

Epilepsia. 1981 Feb;22(1):85-94 PubMed

Neuroscience. 2009 Mar 31;159(3):1070-8 PubMed

Brain Res Dev Brain Res. 1990 Aug 1;55(1):147-50 PubMed

Neuroscience. 2009 Apr 10;159(4):1408-13 PubMed

Prog Neurobiol. 2007 Dec;83(5):277-92 PubMed

Adenosine A1 Receptors Participate in Excitability Changes after Cortical Epileptic Afterdischarges in Immature Rats

A1 not A2A adenosine receptors play a role in cortical epileptic afterdischarges in immature rats