A1 not A2A adenosine receptors play a role in cortical epileptic afterdischarges in immature rats
Language English Country Austria Media print-electronic
Document type Journal Article
- MeSH
- Action Potentials drug effects physiology MeSH
- Analysis of Variance MeSH
- Biophysics MeSH
- Electric Stimulation MeSH
- Rats MeSH
- Cerebral Cortex cytology growth & development MeSH
- Animals, Newborn MeSH
- Rats, Wistar MeSH
- Purinergic Agents pharmacology MeSH
- Receptor, Adenosine A1 metabolism MeSH
- Receptors, Adenosine A2 metabolism MeSH
- Age Factors MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Purinergic Agents MeSH
- Receptor, Adenosine A1 MeSH
- Receptors, Adenosine A2 MeSH
Endo- as well as exogenous adenosine exhibits anticonvulsant action. Participation of individual types of adenosine receptors was studied in present experiments in immature rats. Cortical epileptic afterdischarges were used as a model in rat pups 12, 18 and 25 days old. CCPA, an agonist of A1 adenosine receptors, decreased markedly duration of afterdischarges whereas DPCPX, an antagonist of A1 receptors, exhibited strong proconvulsant action. Action of either drug was best expressed in 12-day-old rats and it decreased with age. Drugs influencing A2A adenosine receptors (agonist CGS21680 and antagonist ZM241385) did not exhibit systematic effects in our model. Motor phenomena accompanying cortical stimulation or epileptic afterdischarge were never influenced by any of the four drugs studied. A1 adenosine receptors are important in the model of cortical seizures, especially in the youngest group studied.
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Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
