Pharmacology of cortical epileptic afterdischarges in rats
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Anticonvulsants pharmacology therapeutic use MeSH
- Dimethyl Sulfoxide pharmacology MeSH
- Electroencephalography drug effects MeSH
- Epilepsies, Myoclonic physiopathology MeSH
- Epilepsy drug therapy physiopathology MeSH
- Phenobarbital pharmacology MeSH
- Phenytoin pharmacology MeSH
- Carbamazepine pharmacology MeSH
- Rats MeSH
- Valproic Acid pharmacology MeSH
- Disease Models, Animal MeSH
- Cerebral Cortex physiopathology MeSH
- Rats, Wistar MeSH
- Severity of Illness Index MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anticonvulsants MeSH
- Dimethyl Sulfoxide MeSH
- Phenobarbital MeSH
- Phenytoin MeSH
- Carbamazepine MeSH
- Valproic Acid MeSH
Afterdischarges (ADs) elicited by electrical stimulation of the sensorimotor cortical area are characterized by rhythmic spikes and spike-wave complexes in the EEG and by clonic face and forelimb seizures. We studied the sensitivity of such ADs to phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), primidone (PRM), and valproate (VPA) in 78 adult male Wistar rats with implanted electrodes. Neither PHT (30 and 60 mg/kg intraperitoneally, i.p.) nor CBZ (25 and 50 mg/kg i.p.) suppressed cortical ADs. Indeed, ADs were prolonged by higher doses of both drugs. PRM had a similar effect: A dose of 40 mg/kg transiently shortened ADs, but a dose of 80 mg/kg prolonged ADs. PB (20 and 40 mg/kg) and VPA (200 and 400 mg/kg) were effective in suppressing ADs. Higher doses of VPA and PB reduced the intensity of motor phenomena related to the stimuli but had no effect on the motor correlates of ADs. These findings suggest that cortically induced ADs are not a good model of secondarily generalized seizures. The response to VPA and PB suggests that cortical ADs may represent a model of myoclonic seizures.
References provided by Crossref.org
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
A1 not A2A adenosine receptors play a role in cortical epileptic afterdischarges in immature rats
Biphasic action of vigabatrin on cortical epileptic after-discharges in rats
