Antagonists of group I metabotropic glutamate receptors and cortical afterdischarges in immature rats
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19486355
DOI
10.1111/j.1528-1167.2009.02091.x
PII: EPI2091
Knihovny.cz E-resources
- MeSH
- Excitatory Amino Acid Antagonists pharmacology MeSH
- Anticonvulsants pharmacology MeSH
- Electroencephalography statistics & numerical data MeSH
- Epilepsy chemically induced physiopathology prevention & control MeSH
- Convulsants pharmacology MeSH
- Rats MeSH
- Receptor, Metabotropic Glutamate 5 MeSH
- Cerebral Cortex drug effects physiopathology MeSH
- Animals, Newborn MeSH
- Pentylenetetrazole pharmacology MeSH
- Motor Activity drug effects physiology MeSH
- Rats, Wistar MeSH
- Pyridines pharmacology MeSH
- Receptors, Metabotropic Glutamate antagonists & inhibitors MeSH
- Receptors, N-Methyl-D-Aspartate MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 6-methyl-2-(phenylethynyl)pyridine MeSH Browser
- Excitatory Amino Acid Antagonists MeSH
- Anticonvulsants MeSH
- Convulsants MeSH
- metabotropic glutamate receptor type 1 MeSH Browser
- Receptor, Metabotropic Glutamate 5 MeSH
- Pentylenetetrazole MeSH
- Pyridines MeSH
- Receptors, Metabotropic Glutamate MeSH
- Receptors, N-Methyl-D-Aspartate MeSH
PURPOSE: Antagonists of group I metabotropic glutamate receptors (mGluRs) are known to exhibit anticonvulsant action without serious side effects. Recently we found anticonvulsant effects of specific antagonists of mGluR subtypes 1 and 5 (AIDA and MTEP) against pentetrazol-induced convulsions in developing rats. In order to determine if the effects of these two antagonists are not exclusively restricted to pentetrazol-induced seizures, we studied their action in a novel seizure model involving immature rats. METHODS: Epileptic afterdischarges were elicited by low-frequency stimulation of sensorimotor cortical region in 12-, 18-, and 25-day-old rats with implanted electrodes. Drugs were administered intraperitoneally after the first afterdischarge: AIDA in doses from 5 to 40 mg/kg; MTEP in doses from 2.5 to 40 mg/kg. The stimulation was then repeated five more times with the same current intensity. Electrocorticographic and motor phenomena were recorded and evaluated. RESULTS: AIDA did not significantly influence movements during stimulation, afterdischarges as well as clonic seizures accompanying afterdischarges. In contrast, MTEP was able to significantly shorten afterdischarges without changes in the two motor phenomena. The effect of MTEP was best expressed in 12-day-old rats; in 25-day-old rats the trials exhibited only a transient shortening of afterdischarges after high doses of MTEP. DISCUSSION: In contrast to similar action against pentetrazol-induced seizures, AIDA and MTEP substantially differ in their action on cortical epileptic afterdischarges. The anticonvulsant action of MTEP in the present model diminishes with age.
References provided by Crossref.org
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
A1 not A2A adenosine receptors play a role in cortical epileptic afterdischarges in immature rats
