Borna disease virus (BDV) circulating immunocomplex positivity in addicted patients in the Czech Republic: a prospective cohort analysis
Jazyk angličtina Země Anglie, Velká Británie Médium electronic
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
20825673
PubMed Central
PMC2944235
DOI
10.1186/1471-244x-10-70
PII: 1471-244X-10-70
Knihovny.cz E-zdroje
- MeSH
- alkoholismus krev imunologie MeSH
- antigeny virové krev imunologie MeSH
- bornaská nemoc imunologie virologie MeSH
- dárci krve statistika a číselné údaje MeSH
- dospělí MeSH
- imunokomplex krev imunologie MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- návykové chování krev imunologie MeSH
- poruchy spojené s užíváním psychoaktivních látek krev imunologie MeSH
- prospektivní studie MeSH
- protilátky virové krev imunologie MeSH
- senioři MeSH
- věkové faktory MeSH
- virus bornaské nemoci imunologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Geografické názvy
- Česká republika MeSH
- Názvy látek
- antigeny virové MeSH
- imunokomplex MeSH
- protilátky virové MeSH
BACKGROUND: Borna disease virus (BDV) is an RNA virus belonging to the family Bornaviridae. Borna disease virus is a neurotropic virus that causes changes in mood, behaviour and cognition. BDV causes persistent infection of the central nervous system. Immune changes lead to activation of infection. Alcohol and drug dependence are associated with immune impairment. METHODS: We examined the seropositivity of BDV circulating immunocomplexes (CIC) in patients with alcohol and drug dependence and healthy individuals (blood donors). We examined 41 addicted patients for the presence of BDV CIC in the serum by ELISA at the beginning of detoxification, and after eight weeks of abstinence. This is the first such study performed in patients with alcohol and drug dependence. RESULTS: BDV CIC positivity was detected in 36.59% of addicted patients on day 0 and in 42.86% on day 56. The control group was 37.3% positive. However, we did not detect higher BDV CIC positivity in addicted patients in comparison with blood donors (p = 0.179). The significantly higher level of BDV CIC was associated with lower levels of GGT (gamma glutamyl transferase) (p = 0.027) and approached statistical significance with the lower age of addicted patients (p = 0.064). We did not find any association between BDV CIC positivity and other anamnestic and demographic characteristics. CONCLUSIONS: In our study addicted patients did not have significantly higher levels of BDV CIC than the control group. The highest levels of BDV CIC were detected in patients with lower levels of GGT and a lower age. TRIAL REGISTRATION: This study was approved by the ethical committee of the University Hospital Medical Faculty of Charles University in Pilsen, Czech Republic (registration number 303/2001).
Zobrazit více v PubMed
Ludwig H, Bode L. Borna disease virus: new aspects on infection, disease, diagnosis and epidemiology. Rev Sci Tech Off Int Epiz. 2000;19(1):259–288. PubMed
Boldogh I, Albrecht T, Porter DD, Baron S, Peské RC, James DA, Susman M, Kennedy CA, Singleton MJD, Schuenke S. In: Medical Microbiology. Samuel Baron, editor. The University of Texas: Medical Branch at Galveston; 1996. Persistent Viral Infections. PubMed
Dietrich DE, Schedlowski M, Bode L, Ludwig H, Emrich HM. A viro-psycho-immunological disease-model of a subtype affective disorder. Pharmacopsychiatry. 1998;31:77–82. doi: 10.1055/s-2007-979305. PubMed DOI
Bode L, Reckwald P, Severu WE, Stoyloff R, Ferszt R, Ditrich DE, Ludwig H. Borna disease virus-specific circulating immune complexes, antigenaemia, and free antibodies - the key marker triplet determining infection and prevailing in severe mood disorders. Mol Psychiatry. 2001;6(4):481–491. doi: 10.1038/sj.mp.4000909. PubMed DOI
Bode L, Ludwig H. Borna disease virus infection, a human mental-health risk. Clin Microbiol Rev. 2003;16(3):534–545. doi: 10.1128/CMR.16.3.534-545.2003. PubMed DOI PMC
Solbrig M, Koob V, George F. Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna disease virus. Pharmacol Biochem Nebav. 2003;74(4):777–787. doi: 10.1016/S0091-3057(03)00019-4. PubMed DOI
Stitz L, Noske K, Planz O, Furrer E, Lipkin WI, Bilzer T. A functional role for neutralizing antibodies in Borna disease: influence of virus tropism outside the central nervous system. J Virol. 1998;72(11):8884–8892. PubMed PMC
Volmer R, Prat ChMA, Masson G, Garenne A, Gonzales-Dunia D. Borna disease virus infection impairs synaptic plasticity. J Virol. 2007;81(16):8833–8837. doi: 10.1128/JVI.00612-07. PubMed DOI PMC
Feschotte C. Borna virus enters the genome. Nature. 2010;463:39–40. doi: 10.1038/463039a. PubMed DOI PMC
Solbrig MV. Animal models of CNS viral disease: Examples from Borna disease virus models. Interdisciplinary Perspectives on Infectious Diseases. 2010;2010:1–6. PubMed PMC
Cotto E, Neau D, Cransac-Neau M, Auriacombe M, Pellegrin JL, Ragnaud JM, Fillet AM, Belnard M, Fleury H, Lafon ME. Borna disease virus RNA in immunocompromised patients in southwestern France. J Clin Microbiol. 2003;41(12):5577–5581. doi: 10.1128/JCM.41.12.5577-5581.2003. PubMed DOI PMC
Bode L, Durrwald R, Rantam FA, Ferszt R, Ludwig H. First isolates of infectious human Borna disease virus from patients with mood disorders. Mol Psychiatry. 1996;1:200–212. PubMed
Rott R, Herzog S, Fleischer B, Winokur A, Amsterdam J, Dyson W, Koprowski H. Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders. Science. 1985;228(4700):755–756. doi: 10.1126/science.3922055. PubMed DOI
Chalmers RM, Thomas DR, Salmon RL. Borna disease virus and the evidence for human pathogenicity: a systematic review. Q J Med. 2005;98:255–274. PubMed
Fukuda K, Takahashi K, Iwata Y, Mori N, Gonda K, Ogawa T, Osonoe K, Sato M, Ogata S, Horimoto T, Sawada T, Tashiro M, Yamaguchi K, Niwa S, Shigeta S. Immunological and PCR analyses for Borna disease virus in psychiatric patients and blood donors in Japan. J Clin Microbiol. 2001;39(2):419–429. doi: 10.1128/JCM.39.2.419-429.2001. PubMed DOI PMC
Iwata Y, Takahashi K, Peng X, Fukuda K, Ohno K, Ogawa T, Gonda K, Mori N, Niwa S, Shigeta S. Detection and sequence analysis of Borna disease virus p24 RNA from peripheral blood mononuclear cells of patients with mood disorders or schizophrenia and of blood donors. J Virol. 1998;72(12):10044–6. PubMed PMC
Tsuji K, Toyomasu K, Imamura Y, Maeda H, Toyoda T. No association of Borna disease virus with psychiatric disorders among patients in northern Kyushu, Japan. J Med Virol. 2000;61(3):336–340. doi: 10.1002/1096-9071(200007)61:3<336::AID-JMV9>3.0.CO;2-P. PubMed DOI
Na KS, Tae SH, Song JW, Kim YK. Failure to detect Borna disease virus antibody and RNA from peripheral blood mononuclear cells of psychiatric patients. Psychiatry Invest. 2009;6:306–312. doi: 10.4306/pi.2009.6.4.306. PubMed DOI PMC
London ED, Simon SL, Berman SM, Mandelkern MA, Lichtman AM, Bramen J, Shinn AK, Miotto K, Learn J, Dong Y, Matochik JA, Kurian V, Newton T, Woods R, Rawson R, Ling W. Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent metamphetamine abusers. Arch Gen Psychiatry. 2004;61:73–84. doi: 10.1001/archpsyc.61.1.73. PubMed DOI
Tomkins DM, Sellers EM. Addiction and the brain: the role of neurotransmitters in the cause and treatment of drug dependence. CMAJ. 2001;164(6):817–821. PubMed PMC
Brown LAS, Cook RT, Jerrells TR, Kolls JK, Nagy LE, Szabo G, Wands JR, Kovacs EJ. Acute and chronic alcohol abuse modulate immunity. Alcohol Clin Exp Res. 2006;30(9):1624–1631. doi: 10.1111/j.1530-0277.2006.00195.x. PubMed DOI
Inabo HI. The relationship between drug abuse and microbial infections. African Journal of Biotechnology. 2005;4(13):1588–1590.
Szabo G. Alcohol's contribution to compromised immunity. Alcohol Health Res World. 1997;21(1):30–41. PubMed PMC
Rackova S, Janu L, Kabickova H. Borna disease virus circulating immunocomplex positivity and psychopathology in psychiatric patients in the Czech Republic. Neuroendocrinol Lett. 2009;30(3):414–419. PubMed
Nunes SO, Itano EN, Amarante MK, Reiche EM, Miranda HC, de Oliveria CE, Matsuo T, Vargas HO, Watanabe MA. RNA from Borna disease virus in patients with schizophrenia schizoaffective disorders and their biological relatives. J Clin Lab Anal. 2008;22:314–320. doi: 10.1002/jcla.20261. PubMed DOI PMC
Thakur R, Sarma S, Sharma B. Role of Borna disease virus in neuropsychiatric illnesses: are we inching closer? Indian J Med Microbiol. 2009;27(3):191–201. doi: 10.4103/0255-0857.53200. PubMed DOI
Rybakowski F, Sawada T, Yamaguchi K. Borna disease virus-reactive antibodies and recent-onset psychiatric disorders. European Psychiatry. 2001;16(3):191–192. doi: 10.1016/S0924-9338(01)00563-6. PubMed DOI
Scholbach T, Bode L. Borna disease virus infection in young children. APMIS. 2008;116(Suppl 124):83–88. doi: 10.1111/j.1600-0463.2008.00m16.x. PubMed DOI
Patti AM, Vulcano A, Candelori E, Donfrancesco R, Ludwig H, Bode L. Borna disease virus infection in Italian children. A potential risk for the developing brain? APMIS. 2008;116(Suppl 124):70–73. doi: 10.1111/j.1600-0463.2008.00m12.x. PubMed DOI
Patti AM, Vulcano A, Candelori E, Travali S. Serological evidence of Borna disease virus infection in children, cats and horses in Sicily (Italy) APMIS. 2008;116(Suppl 124):77–79. doi: 10.1111/j.1600-0463.2008.00m14.x. PubMed DOI
Flower RLP, Kamhieh S, Mclean L, Bode L, Ludwig H, Ward CM. Human Borna disease virus infection in Australia: Serological markers of infection in multi-transfused patients. APMIS. 2008;116(Suppl 124):89–93. doi: 10.1111/j.1600-0463.2008.00m17.x. PubMed DOI
Weisman Y, Huminer D, Malkinson M, Metr R, Klice S, Lipkin WI, Pitlik S. Borna disease virus antibodies among workers exposed to infected ostriches. Lancet. 1994;344:1232–1233. doi: 10.1016/S0140-6736(94)90550-9. PubMed DOI
Takahashi H, Nakaya T, Nakanuta Y, Asahi S, Onishi Y, Ikebuchi K, Takahashi TA, Katoh T, Sekiguchi S, Takazawa M, Tahala H, Ikuta1 K. Higher Prevalence of Borna Disease Virus Infection in Blood Donors Living Near Thoroughbred Horse Farms. J Med Virol. 1997;52:330–335. doi: 10.1002/(SICI)1096-9071(199707)52:3<330::AID-JMV16>3.0.CO;2-M. PubMed DOI
Khan MA, Yamaguchi K, Miytara H, Kazi A, Kamahora T, Hino S. Prevalence of anti-Borna disease virus antipody in horses and their caretakers in Bangladesh. Yonago Acta medica. 2000;43:59–67.
Thomas DR, Chalmers RM, Crook B, Stagg S, Thomas HV, Lewis G, Salmon RL, Caul EO, Morgan KL, Coleman TJ, Morgan-Capner P, Sillist M, Kench SM, Meadows D, Softley P. Borna disease virus and mental health: a cross-sectional study. Q J Med. 2005;98:247–254. PubMed
Pisoni G, Nativi D, Bronzo V, Codazza D. Sero-epidemiological study of Borna disease virus infection in the Italian equine population. Vet Res Commun. 2007;31(Suppl 1):245–248. doi: 10.1007/s11259-007-0016-5. PubMed DOI