Macrophage-assisted inflammation and pharmacological regulation of the cholinergic anti-inflammatory pathway
Language English Country United Arab Emirates Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
21143112
DOI
10.2174/092986711794480140
PII: BSP/CMC/E-Pub/2011/034
Knihovny.cz E-resources
- MeSH
- Acetylcholinesterase metabolism MeSH
- Anti-Inflammatory Agents, Non-Steroidal chemistry therapeutic use MeSH
- Cholinergic Agents chemistry therapeutic use MeSH
- HIV Infections immunology pathology MeSH
- Adrenal Cortex Hormones therapeutic use MeSH
- Humans MeSH
- Macrophages immunology MeSH
- Receptors, Nicotinic metabolism MeSH
- Reactive Oxygen Species metabolism MeSH
- Inflammation drug therapy immunology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- Anti-Inflammatory Agents, Non-Steroidal MeSH
- Cholinergic Agents MeSH
- Adrenal Cortex Hormones MeSH
- Receptors, Nicotinic MeSH
- Reactive Oxygen Species MeSH
Macrophages play an important role in the immune system. They also participate in multiple processes including angiogenesis and triggering of inflammation. The present study summarizes pieces of knowledge on the importance of macrophages in disease, especially the inflammation. Special attention is paid to the cholinergic anti-inflammatory pathway (CAP) associated with the nicotinic acetylcholine receptor (nAChR) and the parasympathetic nervous system. The current pharmacological effectiveness in suppressing the inflammation in general and the septic shock in particular, is limited. CAP was discovered recently and it seems to be a suitable target for the development of new drugs. Moreover, available drugs binding to either nAChR or acetylcholinesterase (AChE) are candidates for either an inhibition or enhancement of CAP. Though the current scientific databases do not include all necessary data on the association of CAP with body functions and the research is quite intensive, the objective of the present review is to introduce the current trends and to critically evaluate CAP and macrophage-associated pathways.
References provided by Crossref.org
Performance of bat-derived macrophages at different temperatures
Role of oxidative stress in infectious diseases. A review
Alpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology
