MicroRNAs and their target gene networks in renal cell carcinoma
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
21232526
DOI
10.1016/j.bbrc.2011.01.019
PII: S0006-291X(11)00038-6
Knihovny.cz E-zdroje
- MeSH
- apoptóza genetika MeSH
- genové regulační sítě * MeSH
- hypoxie buňky MeSH
- invazivní růst nádoru MeSH
- karcinom z renálních buněk genetika patologie MeSH
- lidé MeSH
- metastázy nádorů MeSH
- mikro RNA genetika metabolismus MeSH
- nádory ledvin genetika patologie MeSH
- proliferace buněk MeSH
- regulace genové exprese u nádorů * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- mikro RNA MeSH
MicroRNAs (miRNAs) are non-protein-coding short single stranded RNAs in the size range 19-25 nucleotides that are associated with gene regulation at the transcriptional and translational level. Recent studies have proved that miRNAs play important roles in a large number of biological processes, including cellular differentiation, proliferation, apoptosis, etc. Changes in their expression were found in a variety of human cancers, including renal cell carcinoma pathogenesis. Specific miRNA alterations were associated with key pathogenetic mechanisms of renal cell carcinoma like hypoxia or epithelial-mesenchymal transition. In this review, we summarize the current knowledge of miRNA functions in renal cell carcinoma with an emphasis on miRNAs potential to serve as a powerful biomarker of disease and a novel therapeutic target in oncology.
Citace poskytuje Crossref.org
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