MicroRNAs and their target gene networks in renal cell carcinoma
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
21232526
DOI
10.1016/j.bbrc.2011.01.019
PII: S0006-291X(11)00038-6
Knihovny.cz E-resources
- MeSH
- Apoptosis genetics MeSH
- Gene Regulatory Networks * MeSH
- Cell Hypoxia MeSH
- Neoplasm Invasiveness MeSH
- Carcinoma, Renal Cell genetics pathology MeSH
- Humans MeSH
- Neoplasm Metastasis MeSH
- MicroRNAs genetics metabolism MeSH
- Kidney Neoplasms genetics pathology MeSH
- Cell Proliferation MeSH
- Gene Expression Regulation, Neoplastic * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- MicroRNAs MeSH
MicroRNAs (miRNAs) are non-protein-coding short single stranded RNAs in the size range 19-25 nucleotides that are associated with gene regulation at the transcriptional and translational level. Recent studies have proved that miRNAs play important roles in a large number of biological processes, including cellular differentiation, proliferation, apoptosis, etc. Changes in their expression were found in a variety of human cancers, including renal cell carcinoma pathogenesis. Specific miRNA alterations were associated with key pathogenetic mechanisms of renal cell carcinoma like hypoxia or epithelial-mesenchymal transition. In this review, we summarize the current knowledge of miRNA functions in renal cell carcinoma with an emphasis on miRNAs potential to serve as a powerful biomarker of disease and a novel therapeutic target in oncology.
References provided by Crossref.org
MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma
Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer
Novel classes of non-coding RNAs and cancer
Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma
